Developmental changes in the corpus callosum from infancy to early adulthood: a structural magnetic resonance imaging study

PloS One
Megumi M Tanaka-ArakawaKyo Noguchi

Abstract

Previous research has reported on the development trajectory of the corpus callosum morphology. However, there have been only a few studies that have included data on infants. The goal of the present study was to examine the morphology of the corpus callosum in healthy participants of both sexes, from infancy to early adulthood. We sought to characterize normal development of the corpus callosum and possible sex differences in development. We performed a morphometric magnetic resonance imaging (MRI) study of 114 healthy individuals, aged 1 month to 25 years old, measuring the size of the corpus callosum. The corpus callosum was segmented into seven subareas of the rostrum, genu, rostral body, anterior midbody, posterior midbody, isthmus and splenium. Locally weighted regression analysis (LOESS) indicated significant non-linear age-related changes regardless of sex, particularly during the first few years of life. After this increase, curve slopes gradually became flat during adolescence and adulthood in both sexes. Age of local maximum for each subarea of the corpus callosum differed across the sexes. Ratios of total corpus callosum and genu, posterior midbody, as well as splenium to the whole brain were significantly higher in...Continue Reading

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Citations

Apr 21, 2020·American Journal of Human Biology : the Official Journal of the Human Biology Council·Magdalena Babiszewska
Sep 27, 2020·The Journal of Comparative Neurology·René WesterhausenWilliam D Hopkins
Dec 14, 2018·AJNR. American Journal of Neuroradiology·K L KrauseJ M Pollock
Jun 23, 2020·Journal of Alzheimer's Disease : JAD·Maggie RoyMaxime Descoteaux
Mar 21, 2020·AJNR. American Journal of Neuroradiology·E SchnebleJ M Pollock

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