Developmental changes in the effects of prostaglandin E2 in the chicken ductus arteriosus.

Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
Pia AgrenEduardo Villamor

Abstract

Prostaglandin E(2) (PGE(2)) is the major vasodilator prostanoid of the mammalian ductus arteriosus (DA). In the present study we analyzed the response of isolated DA rings from 15-, 19- and 21-day-old chicken embryos to PGE(2) and other vascular smooth muscle relaxing agents acting through the cyclic AMP signaling pathway. PGE(2) exhibited a relaxant response in the 15-day DA, but not in the 19- and 21-day DA. Moreover, high concentrations of PGE(2) (>or= 3 microM in 15-day and >or= 1 microM in 19-day and 21-day DA) induced contraction of the chicken DA. The presence of the TP receptor antagonist SQ29,548, unmasked a relaxant effect of PGE(2) in the 19- and 21-day DA and increased the relaxation induced by PGE(2) in the 15-day DA. The presence of the EP receptor antagonist AH6809 abolished PGE(2)-mediated relaxation. The relaxant responses induced by PGE(2) and the beta-adrenoceptor agonist isoproterenol, but not those elicited by the adenylate cyclase activator forskolin or the phosphodiesterase 3 inhibitor milrinone, decreased with maturation. High oxygen concentrations (95%) decreased the relaxation to PGE(2). The relaxing potency and efficacy of isoproterenol and milrinone were higher in the pulmonary than in the aortic sid...Continue Reading

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Citations

Nov 26, 2009·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Bea ZoerEduardo Villamor
Jun 1, 2011·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Rob M Moonen, Eduardo Villamor
Aug 4, 2012·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D R HarlandM Medhora
May 14, 2011·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Saskia van der Sterren, Eduardo Villamor
Apr 26, 2011·Respiratory Physiology & Neurobiology·Edward M DzialowskiEduardo Villamor
May 22, 2010·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Marijn J Schuurman, E Villamor
Jun 30, 2015·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Riazudin MohammedEduardo Villamor
Jul 15, 2015·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Henry Greyner, Edward M Dzialowski
Mar 22, 2019·PloS One·Toru AkaikeSusumu Minamisawa
Aug 5, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Saskia van der SterrenEduardo Villamor
Jul 21, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Angel L CogolludoEduardo Villamor
Feb 19, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Thijs W H FlinsenbergEduardo Villamor

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