Developmental changes in the expression pattern of the JNK activator kinase MUK/DLK/ZPK and active JNK in the mouse cerebellum

Cell and Tissue Research
Jun SuenagaSyu-ichi Hirai

Abstract

JNK is one of the key molecules regulating cell differentiation and migration in a variety of cell types, including cerebral cortical neurons. MUK/DLK/ZPK belongs to the MAP kinase-kinase-kinase class of protein kinases for the JNK pathway and is expressed predominantly in neural tissue. We have determined the expression pattern of MUK/DLK/ZPK and active JNK in the cerebellum at different stages of postnatal development. Quantitative analysis by Western blotting has showed that high expression levels of MUK/DLK/ZPK and active JNK are maintained during the postnatal development of the cerebellum, and that these levels decrease in the adult cerebellum. Immunohistochemical staining has revealed, however, that their distribution in the developing cerebellum is considerably different. Although active JNK is highly concentrated in the premigratory zone of the external germinal layer (EGL), high expression of MUK/DLK/ZPK has been observed in the molecular layer and in the premigratory zone. Neither the active JNK nor MUK protein has been detected in the proliferative zone of the EGL. These observations suggest that during the postnatal development of the cerebellum, the MUK-JNK signaling pathway contributes to the regulation of granul...Continue Reading

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Citations

Jun 25, 2008·Journal of Molecular Neuroscience : MN·A Falluel-MorelB J Gonzalez
Aug 17, 2010·Yi chuan = Hereditas·Xian-Jue Ma, Lei Xue
Nov 27, 2007·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Yiming SunZhiheng Xu
Oct 9, 2019·Annual Review of Cell and Developmental Biology·Yishi Jin, Binhai Zheng

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