Developmental changes in the flotillin-1 expression pattern of the rat visual cortex

Neuroscience
K Nakadate

Abstract

Ocular dominance plasticity is activity dependent, changes in response to eye competition, and is transitory during developmental stages. Lipid rafts have modulatory functions in cellular, physiological, and behavioral processes. Although many of these modulatory roles are mediated by flotillin-1, a lipid raft-associated protein, the ontogenetic changes in the cellular and subcellular distribution patterns of flotillin-1 are unclear. I investigated the developmental pattern of the distribution of flotillin-1 in the rat visual cortex with immunohistochemistry at both light and electron microscopic levels. An affinity-purified anti-flotillin-1 antibody reacted with a single band of about 40-50 kDa in total proteins prepared from the rat visual cortex. Flotillin-1 levels transiently increased on postnatal days 21-35. Flotillin-1 immunoreactivity at 3 weeks of age was broadly distributed though all visual cortical layers, but it exhibited a relatively higher density in layers II/III and V/VI. Flotillin-1 immunoreactivity at 3 months of age was significantly decreased compared with that at 3 weeks of age. Strong flotillin-1 immunoreactivity was observed in both neuronal perikarya and processes at 3 weeks of age. Double-labeling expe...Continue Reading

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Citations

Jun 29, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Mouhamed AlsaqatiEmma J Kidd
Oct 23, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Kazuhiko NakadateSawako Tanaka-Nakadate
Sep 5, 2019·International Journal of Molecular Sciences·Verica VasicMirko H H Schmidt
Jul 3, 2021·Frontiers in Psychiatry·Niels HansenCharles Timäus

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