PMID: 8612328Nov 21, 1995Paper

Developmental changes in the localization of the transplasma membrane NADH-dehydrogenases in the rat brain

Brain Research. Developmental Brain Research
Y Yong, J L Dreyer

Abstract

The function of transplasma membrane oxidoreductases (PMO's) has been further studied by means of investigating the postnatal (PN) developmental changes in the tissue localization of six isoenzymes previously characterized (see accompanying paper). The changes were followed in the midbrain for PMO-I, -II, and -V and in the brainstem for PMO-III, -IV and -VI. PMO-I is not observed before PN5 and develops as long vertical fibers located mainly in the pontine nucleus and in the dorsal raphe nucleus until it merges all over the midbrain except for the aqueduct and the superior colliculus after PN10. At that stage it is highly expressed in the trigeminal nucleus and the dorsal raphe, but its expression then strongly decreases and PMO-I disappears almost completely later on. Similarly PMO-II only develops around PN5, first in the dorsal and caudal linear raphe and later on (at PN7) also in the pontine nucleus and in the median raphe; at PN10 PMO-II gradually had vanished from these areas and strongly developed in the dorsal raphe and in the mesencephalic trigeminal nucleus. Later on PMO-II also decreases from these areas. PMO-III slowly develops within the gigantocellular reticular nucleus from PN1 to PN5 and later on reaches the fac...Continue Reading

References

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Nov 21, 1995·Brain Research. Developmental Brain Research·Y Yong, J L Dreyer

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