Developmental changes in the orexin 2 receptor mRNA in hypoglossal motoneurons

Neuroreport
Denys V VolginL Kubin

Abstract

Hypothalamic orexin-containing neurons project to many CNS targets, including motoneurons. We assessed developmental changes in the expression of the orexin type 2 receptor (ORX2r) mRNA in hypoglossal (XII) motoneurons. Identified motoneurons were dissociated from 4- to 33-day-old rats and subjected to single-cell reverse transcription and PCR; nearly all contained the ORX2r mRNA. In 40 motoneurons studied using semi-nested PCR, and in another 39 subjected to quantitative, real-time PCR, the number of reverse-transcribed mRNA copies per cell was significantly higher around day 20 postnatally than at any other age. Thus, ORX may postsynaptically excite XII motoneurons, with the ORX2r mRNA production increased during the critical period for development of the rapid eye movement sleep and its disorder narcolepsy/cataplexy.

References

Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·L de LeceaJ G Sutcliffe
Aug 26, 1998·Experimental Neurology·J RiehlE Mignot
Jul 13, 2000·Brain Research. Molecular Brain Research·Y YamamotoH Yamashita
Jul 25, 2000·Trends in Neurosciences·T S Kilduff, C Peyron
Mar 29, 2001·Autonomic Neuroscience : Basic & Clinical·J K Phillips, J Lipski
Apr 3, 2001·Annual Review of Neuroscience·J T WillieM Yanagisawa
Apr 11, 2001·Brain Research. Molecular Brain Research·M A Greco, P J Shiromani
Apr 12, 2001·The Journal of Comparative Neurology·A N Van Den PolX B Gao
May 23, 2001·The Journal of Comparative Neurology·J N MarcusJ K Elmquist

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Citations

Jun 9, 2005·Neuroscience Letters·Wei ZhangTomoyuki Kuwaki
Oct 3, 2008·Expert Reviews in Molecular Medicine·Rhîannan H Williams, Denis Burdakov
Sep 25, 2008·Current Opinion in Pulmonary Medicine·Christian GestreauMathias Dutschmann
Sep 6, 2008·Journal of Applied Physiology·Denys V VolginLeszek Kubin
May 15, 2013·Respiratory Physiology & Neurobiology·Denys V VolginLeszek Kubin
Sep 4, 2010·Autonomic Neuroscience : Basic & Clinical·Tomoyuki Kuwaki
Apr 27, 2010·Respiratory Physiology & Neurobiology·Tomoyuki Kuwaki, Wei Zhang
Apr 29, 2008·Autonomic Neuroscience : Basic & Clinical·Tomoyuki KuwakiBen-Shiang Deng
Jun 3, 2008·Respiratory Physiology & Neurobiology·Leszek Kubin, Denys V Volgin
May 27, 2016·Temperature : Multidisciplinary Biomedical Journal·Tomoyuki Kuwaki
Apr 3, 2003·The European Journal of Neuroscience·Denys V VolginLeszek Kubin
May 23, 2014·British Journal of Pharmacology·G H ZhangL L Shen
Jun 9, 2004·Neuroscience Letters·Arijit RoySukhamay Lahiri
May 30, 2006·Autonomic Neuroscience : Basic & Clinical·Denys V Volgin, Leszek Kubin
Dec 22, 2010·Neuron·Clifford B SaperThomas E Scammell
Jun 13, 2003·Clinics in Chest Medicine·Sigrid Carlen Veasey
Nov 24, 2004·Journal of Applied Physiology·John K YoungMusa A Haxhiu
Jan 18, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Wei ZhangTomoyuki Kuwaki

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