Developmental changes in the sensitivity of the chick embryo ventricle to beta-adrenergic agonist during adrenergic innervation

Circulation Research
D Higgins, A J Pappano

Abstract

As early as the 4th embryonic day, the ventricle of the chick embryo responded to isoproterenol (Iso) with an increase in the force of contraction; at all ages studied, this positive inotropic effect was accompanied by an increased rate of tension development. There was a transient, 10-fold decrease in the sensitivity (increase in ED50) of the right ventricle to Iso between the 16th and 21st embryonic day. This change in the sensitivity to Iso was not due either to an increased inactivation of Iso by non-neuronal cells or to a change in the thickness of the ventricle. It was found that adrenergic nerves were first capable of altering ventricular contractility on the 16th embryonic day. Whereas they interfered with the function of adrenergic nerves, injections of reserpine or 6-hydroxydopamine had no effect on the subsensitivity to Iso. Furthermore, these agents did not affect the normal developmental changes in heart weight. We conclude that the local release of transmitter from adrenergic nerves does not cause the transient subsensitivity of the ventricle of the chick embryo to beta-adrenergic agonists.

References

Feb 5, 1979·Life Sciences·K D MeisheriJ H McNeill
Jul 1, 1979·Journal of Molecular and Cellular Cardiology·D Higgins, A J Pappano
Apr 1, 1979·Canadian Journal of Physiology and Pharmacology·W A BehrensF Depocas
Jan 1, 1979·Developmental Neuroscience·G M FrieswickF E Shideman
Jan 1, 1977·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·I M Taylor
Jan 1, 1975·Biochemical Pharmacology·C Sachs, G Jonsson
Oct 1, 1974·Journal of Molecular and Cellular Cardiology·N Sperelakis, K Shigenobu
Oct 1, 1965·The American Journal of Physiology·A DahlströmB E Zetterström

❮ Previous
Next ❯

Citations

Jan 1, 1983·Pharmacology & Therapeutics·N Sperelakis, A J Pappano
Apr 1, 1997·Journal of Physiology, Paris·N A AhmedM M Abd el-Salam
Mar 19, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Joachim HöchelMartin Nichelmann
Feb 22, 2000·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·J HöchelH Tazawa
Mar 3, 2001·Pediatric Research·R RomanoE Raddatz
Jan 16, 2007·Journal of Pharmacological Sciences·Hideaki NouchiKoki Shigenobu
Jul 28, 2004·Journal of Molecular and Cellular Cardiology·Jihong Qu, Richard B Robinson
Oct 27, 2016·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Prajakta A DhageShobha Y Bhargava
May 8, 1983·FEBS Letters·H WillC Kemsies
May 22, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Isa Lindgren, Jordi Altimiras
Aug 24, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D Crossley, J Altimiras
Feb 13, 2003·The Journal of Experimental Biology·Sandra Stekelenburg-de VosRobert E Poelmann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.