Developmental changes in UDP-N-acetylglucosamine 2-epimerase activity of rat and guinea-pig liver

Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
B GalP Hueso

Abstract

The activity of UDP-N-acetylglucosamine 2-epimerase was determined in the liver of rats and guinea-pigs of different ages. The activity of this enzyme in rats was low at birth, increased to a maximum value on day 15, and fell gradually until day 30. Thereafter, it increased up to the 60th day. The activity profile of the enzyme from guinea-pig liver was very similar. However, guinea-pig activity was 2-5 times lower than in rats. Both rats and guinea-pigs displayed similar liver sialic acid contents which increased from birth to 2 months of age. Rats also showed a N-glycolylneuraminic acid content that decreased from birth to 2 months. From these results we can inferred that postnatal UDP-N-acetylglucosamine 2-epimerase activity seems to be correlated with age and the developmental states of rats and guinea-pigs.

Citations

Apr 8, 2010·Journal of Agricultural and Food Chemistry·Nannan TaoCarlito B Lebrilla
Nov 26, 2010·Glycobiology·Jovana MaksimovicKeith Savin
Jul 7, 2009·Annual Review of Nutrition·Bing Wang
Dec 17, 2009·PloS One·Peter I DuncanNorbert Sprenger
Oct 25, 2003·European Journal of Clinical Nutrition·B Wang, J Brand-Miller
Jul 8, 2016·Nature·Mark R CharbonneauJeffrey I Gordon
Jun 1, 2001·Journal of Dairy Science·M J MartínP Hueso
Feb 8, 2007·The American Journal of Clinical Nutrition·Bing WangJennie Brand-Miller

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