Developmental changes of connexin40 and connexin43 mRNA distribution patterns in the rat heart

Cardiovascular Research
Marjan J A van KempenW H Lamers

Abstract

Gap junctions have been demonstrated ultrastructurally in cardiac regions where connexin40 (Cx40) and connexin43 (Cx43) protein could not be detected immunohistochemically. We investigated therefore the distribution of their mRNAs with more sensitive techniques. In situ hybridizations with Cx40 and Cx43 cRNA probes were performed on sections of rat hearts from 9 embryonic days (ED 9) to adults. From ED 13, Cx40 and Cx43 mRNA are detectable in atria and ventricles, but not in their flanking myocardium (inflow tract, atrioventricular canal and outflow tract). Even though Cx40 and Cx43 mRNA eventually become expressed in the inflow tract, they remain undetectable in the sinoatrial node, the atrioventricular canal (including atrioventricular node) and outflow tract. Expression of Cx40 is maximal in the fetal period and declines towards birth. Cx40 expression in the left and right ventricles evolves independently, its mRNA disappearing 4 days earlier from the right than from the left ventricle, and earlier from the free wall than from the trabeculations. Expression of Cx43 mRNA increases during development and changes postnatally from uniform to punctate. Prenatally, Cx43 mRNA was strongest in the subepicardial layer of the ventricu...Continue Reading

Citations

Feb 7, 2012·Pediatric Cardiology·Hongbing LiuYiping Chen
Jan 29, 2008·Biological Trace Element Research·Veronica LopezLouise Lanoue
Apr 7, 2000·Brain Research. Brain Research Reviews·C M Frenz, T R Van De Water
Mar 24, 2011·Cardiovascular Research·Diego FrancoAmelia Aránega
Apr 24, 2012·Cardiovascular Research·Steven N Ebert
May 29, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Teun P de BoerToon A B van Veen
Mar 14, 2002·Biochemical and Biophysical Research Communications·Birgit E J TeunissenMarti F A Bierhuizen
Mar 18, 2008·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·T P de BoerT A B van Veen
Oct 21, 2010·Cellular and Molecular Life Sciences : CMLS·Shoji Maeda, Tomitake Tsukihara
Feb 28, 2004·Trends in Cardiovascular Medicine·C W Lo, A Wessels
Jan 15, 2004·Trends in Cardiovascular Medicine·Eric M Small, Paul A Krieg
Jan 24, 2006·The Veterinary Journal·Changbaig Hyun, Lucio J Filippich
Mar 5, 2003·Trends in Molecular Medicine·Ching-Feng ChengKenneth R Chien
Oct 31, 2006·Journal of Molecular and Cellular Cardiology·William R MillsKenneth R Laurita
Mar 3, 2007·The Journal of Pharmacy and Pharmacology·Sandra A Jones
Feb 17, 2006·Biochemical and Biophysical Research Communications·Mladen PavlovicSabina Gallati
Mar 16, 2007·Differentiation; Research in Biological Diversity·Teun P de BoerMarcel A G van der Heyden
Jun 18, 2004·Annals of the New York Academy of Sciences·Antoon F M MoormanVincent M Christoffels
Jun 7, 2011·Developmental Biology·Ramón A Espinoza-LewisYiPing Chen
Sep 25, 2009·International Journal of Cardiology·Cornelia WieseAnna M Wobus
Apr 7, 2009·Journal of Molecular and Cellular Cardiology·Maartje NoormanHarold V M van Rijen
Jul 7, 2000·Developmental Biology·V M ChristoffelsA F Moorman
Jan 27, 2009·Developmental Biology·Ramón A Espinoza-LewisYiPing Chen
Jan 21, 2004·Developmental Biology·Alexander M SimonHwuDauRw Chen
Mar 26, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Vincent M ChristoffelsMarina Campione
Mar 9, 2012·Regenerative Medicine·Brian LiauNenad Bursac
Oct 8, 2009·Circulation. Arrhythmia and Electrophysiology·Vincent M Christoffels, Antoon F M Moorman
May 10, 2008·Circulation Research·Martijn L BakkerVincent M Christoffels
Feb 6, 2010·Circulation Research·Vincent M ChristoffelsAntoon F M Moorman
Mar 5, 1998·Circulation Research·J YaW H Lamers
Oct 17, 2013·Circulation. Arrhythmia and Electrophysiology·Margo J H van CampenhoutNatasja M S de Groot
Apr 18, 1998·Circulation Research·A F MoormanW H Lamers
Jun 26, 1999·Circulation Research·S AlcoléaD B Gros
Jan 1, 2019·PloS One·Alejandro Salguero-JiménezJosé Luis de la Pompa

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