PMID: 22827873Aug 1, 2012Paper

Developmental changes of the sensitivity of cardiac and liver mitochondrial permeability transition pore to calcium load and oxidative stress

Physiological Research
Zdenek DrahotaB Ošt'ádal


Opening of the mitochondrial membrane permeability transition pore (MPTP) is an important factor in the activation of apoptotic and necrotic processes in mammalian cells. In a previous paper we have shown that cardiac mitochondria from neonatal rats are more resistant to calcium load than mitochondria from adult animals. In this study we have analyzed the ontogenetic development of this parameter both in heart and in liver mitochondria. We found that the high resistance of heart mitochondria decreases from day 14 to adulthood. On the other hand, we did not observe a similar age-dependent sensitivity in liver mitochondria, particularly in the neonatal period. Some significant but relatively smaller increase could be observed only after day 30. When compared with liver mitochondria cardiac mitochondria were more resistant also to the peroxide activating effect on calcium-induced mitochondrial swelling. These data thus indicate that the MPTP of heart mitochondria is better protected against damaging effects of the calcium load and oxidative stress. We can only speculate that the lower sensitivity to calcium-induced swelling may be related to the higher ischemic tolerance of the neonatal heart.


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Feb 11, 2003·Analytical Biochemistry·Irina S GostimskayaAndrei D Vinogradov
Mar 29, 2005·The Journal of Biological Chemistry·Emy BassoPaolo Bernardi
Jun 15, 2005·Biochimica Et Biophysica Acta·Fernanda RicchelliSergio Bova
Nov 21, 2008·Archives of Toxicology·Zuzana CervinkováZdenek Drahota
Apr 10, 2009·Journal of Bioenergetics and Biomembranes·Andrew P Halestrap
Sep 17, 2009·Molecular and Cellular Biochemistry·Marie MilerovaBohuslav Ostadal
Apr 14, 2010·Biochimica Et Biophysica Acta·Ernesto Carafoli
May 24, 2011·Cell Calcium·Andrea Rasola, Paolo Bernardi
Jun 15, 2011·Mitochondrion·Alena PecinováJosef Houštěk

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