Developmental Changes Within the Genetic Architecture of Social Communication Behavior: A Multivariate Study of Genetic Variance in Unrelated Individuals.

Biological Psychiatry
Beate St PourcainGeorge Davey Smith

Abstract

Recent analyses of trait-disorder overlap suggest that psychiatric dimensions may relate to distinct sets of genes that exert maximum influence during different periods of development. This includes analyses of social communication difficulties that share, depending on their developmental stage, stronger genetic links with either autism spectrum disorder or schizophrenia. We developed a multivariate analysis framework in unrelated individuals to model directly the developmental profile of genetic influences contributing to complex traits, such as social communication difficulties, during an approximately 10-year period spanning childhood and adolescence. Longitudinally assessed quantitative social communication problems (N ≤ 5551) were studied in participants from a United Kingdom birth cohort (Avon Longitudinal Study of Parents and Children; age range, 8-17 years). Using standardized measures, genetic architectures were investigated with novel multivariate genetic-relationship-matrix structural equation models incorporating whole-genome genotyping information. Analogous to twin research, genetic-relationship-matrix structural equation models included Cholesky decomposition, common pathway, and independent pathway models. A two...Continue Reading

Citations

Jan 25, 2018·Annals of the New York Academy of Sciences·Devanand S Manoli, Jessica Tollkuhn
Jan 22, 2019·Nature Communications·Simon HaworthBeate St Pourcain
Sep 15, 2020·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Ellen VerhoefBeate St Pourcain
Apr 20, 2018·Journal of Child Psychology and Psychiatry, and Allied Disciplines·William MandyJon Heron
Mar 7, 2018·Biological Psychiatry·Richard P Ebstein
Jun 23, 2021·Psychological Medicine·Richard PenderWill Mandy

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Methods Mentioned

BETA
chip
genotyping

Software Mentioned

R for
R
OpenMx FIML
R gsem
GSEMs
GREML
OpenMx
GCTA GREML
GCTA GREML )
Genome

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