Developmental control of cell cycle regulators: a fly's perspective

Science
B A Edgar, C F Lehner

Abstract

During early development in many species, maternally supplied gene products permit the cell cycle to run at maximum velocity, subdividing the fertilized egg into smaller and smaller cells. As development proceeds, zygotic controls are activated that first limit divisions to defined spatial and temporal domains, coordinating them with morphogenesis, and then halt proliferation altogether, to allow cell differentiation. Analysis of the regulation of cyclin-dependent kinases (Cdks) in Drosophila has provided insights into how this embryonic program of cell proliferation is controlled at the molecular level and how it is linked to developmental cues. Recent studies have also begun to reveal how cell proliferation is controlled during the second phase of Drosophila development, which occurs in imaginal tissues. In contrast to their embryonic progenitors, imaginal cells proliferate with a cycle that requires cell growth and is linked to patterning processes controlled by secreted cell signaling molecules. The functions of these signaling molecules appear to be nearly as conserved between vertebrates and invertebrates as the cell cycle control apparatus itself, suggesting that the mechanisms that coordinate growth, patterning, and cel...Continue Reading

References

Sep 10, 1976·Science·V FrenchS V Bryant
Jan 1, 1976·Developmental Biology·A Garcia-BellidoG Morata
May 1, 1971·Transplantation·B I LeitinaS N Zinzar
Jun 1, 1981·Experimental Cell Research·P N Adler, M MacQueen
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·T L Orr-Weaver
Dec 14, 1995·Nature·A VogelJ C Izpisúa Belmonte
Jun 1, 1995·Current Biology : CB·E P BrandonG S McKnight
Jan 1, 1994·Journal of Cell Science. Supplement·K L WatsonP J Bryant
Jun 1, 1994·Mechanisms of Development·M González-GaitánA García-Bellido
Nov 18, 1994·Cell·C J Sherr
Sep 1, 1994·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·H Meinhardt
Nov 15, 1994·The Journal of Experimental Zoology·D L Frederick, M T Andrews
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·B D DynlachtN Dyson
Feb 1, 1993·The Journal of Cell Biology·P HartlD J Forbes
Feb 26, 1993·Cell·G Struhl, K Basler
Mar 25, 1993·Nature·K S McKimR S Hawley
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·M MilánA García-Bellido

❮ Previous
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Citations

Jun 10, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·L A Johnston
Apr 10, 2013·Trends in Cell Biology·Hirofumi HarashimaArp Schnittger
Feb 28, 2003·Developmental Biology·Thomas M BrodiganMichael Krause
May 29, 2003·Journal of Insect Physiology·R B.R. AzevedoL Partridge
May 29, 2003·Journal of Insect Physiology·V FrenchL Partridge
Jan 19, 2000·Trends in Genetics : TIG·C J PotterT Xu
Jan 8, 1999·Biochimica Et Biophysica Acta·M A Kukuruzinska, K Lennon-Hopkins
Jul 11, 1998·Biochimica Et Biophysica Acta·M A FarrarK Sauer
Oct 21, 1999·Biochimica Et Biophysica Acta·G S TurenchalkT Xu
Jan 23, 1999·Current Opinion in Cell Biology·T P Neufeld, B A Edgar
Feb 7, 2001·Current Opinion in Biotechnology·B G den Boer, J A Murray
Mar 11, 1999·Current Opinion in Genetics & Development·R J Duronio
Feb 17, 2001·Current Opinion in Neurobiology·C W Ragsdale, E A Grove
Nov 24, 2001·Trends in Cell Biology·P H O'Farrell
Dec 24, 2002·Current Opinion in Plant Biology·Frédéric Berger
Apr 25, 2003·Gene Expression Patterns : GEP·Ann E Vernon, Anna Philpott
Oct 1, 2003·Respiratory Physiology & Neurobiology·Limei Zhou, Marc B Hershenson
Feb 5, 2008·Nature Genetics·Edward Owusu-AnsahUtpal Banerjee
Aug 23, 2008·Nature Reviews. Molecular Cell Biology·Sander van den Heuvel, Nicholas J Dyson
Jun 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Narottam AcharyaSatya Prakash
Apr 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Justin Courcelle
Jul 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jung-Hoon YoonLouise Prakash
Dec 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Malcolm J LippertSue Jinks-Robertson
Oct 9, 2013·The Journal of Cell Biology·Tamar Listovsky, Julian E Sale
Sep 10, 2009·Stem Cells and Development·Zuzana KoledovaVladimir Divoky
Jul 3, 2010·Stem Cells and Development·Zuzana KoledovaVladimir Divoky
Jun 8, 1999·Molecular Biology of the Cell·J C MigeonB A Edgar
Jul 3, 2002·The EMBO Journal·Anthony M BrumbyHelena Richardson
Oct 28, 1999·Nucleic Acids Research·W LinZ Wang
Apr 2, 1999·Nucleic Acids Research·V M MarathiasP H Bolton
Feb 16, 2008·Nucleic Acids Research·Amy L AbdulovicSue Jinks-Robertson
Jun 15, 2011·Nucleic Acids Research·The Vinh HoOrlando D Schärer
Nov 15, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Julian E SaleDávid Szüts
Feb 28, 1998·Genes & Development·S LarochelleB Suter
Aug 21, 2001·Genes & Development·D M PanchisionR D McKay

❮ Previous
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