PMID: 2497464May 1, 1989Paper

Developmental control of lymphokine gene expression in fetal thymocytes during T-cell ontogeny

Proceedings of the National Academy of Sciences of the United States of America
S R CardingJ J Owen

Abstract

We have used the technique of in situ hybridization to investigate the expression of lymphokine genes by immature thymocytes during intrathymic development. In 13-day fetal thymocytes a population of cells constitutively produces low levels of interleukin 2 (IL-2) and interleukin 4 (IL-4) mRNAs. A second phase of lymphokine gene expression occurs in the majority of 15-day thymocytes, and a population of cells constitutively produces both IL-2 and IL-4 mRNAs. Thymocytes at 14 days of gestation and after 16 days up until birth do not express detectable lymphokine mRNA. By contrast, the population of IL-2 receptor mRNA-producing thymocytes increases progressively up to 15 days of gestation, and expression thereafter decreases up to birth. In addition, thymocytes expressing interferon gamma mRNA were not present until just prior to birth. Our findings indicate developmental control of lymphokine and lymphokine receptor gene expression in fetal thymocytes during ontogeny.

References

Jan 1, 1988·European Journal of Immunology·M J OwenJ J Owen
Jun 1, 1987·The Journal of Experimental Medicine·D M PardollR H Schwartz
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M E HarperF Wong-Staal
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P SiderasR Palacios
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A ZlotnikM Howard
May 1, 1985·European Journal of Immunology·S HabuE M Shevach
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·P W Gray, D V Goeddel
Mar 1, 1983·European Journal of Immunology·R CeredigE J Jenkinson

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Citations

Dec 1, 1989·Current Opinion in Immunology·A Kelso
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S KyesA Hayday
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A BárcenaC Martínez-A
Jan 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J C Gutierrez, R Palacios
Jan 1, 1991·The Journal of Experimental Medicine·D B LewisR M Perlmutter
Feb 1, 1993·The Journal of Experimental Medicine·S R CardingP C Doherty
Dec 1, 1992·Scandinavian Journal of Immunology·G LeclercqJ Plum
Feb 1, 1991·Immunological Reviews·D EmilieB Malissen
Jan 1, 1992·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·D GigliottiM Hansson
Jul 1, 1991·Immunology Today·S R CardingK Bottomly
Sep 25, 1999·Seminars in Immunology·G A Holländer
Sep 5, 1998·Immunity·I RivièreD R Littman
Apr 1, 1992·European Journal of Immunology·M V WilesB A Imhof
Dec 1, 1991·Immunology and Cell Biology·M Lipoldová, V Holán
Jun 1, 1990·European Journal of Immunology·S R CardingK Bottomly
Jul 1, 1991·European Journal of Immunology·G LeclercqJ Plum
Jul 1, 1991·European Journal of Immunology·I LibermanD Rueff-Juy

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