Developmental coordination disorder: a pilot diffusion tensor imaging study

Pediatric Neurology
Jill G ZwickerLara A Boyd

Abstract

Motor deficits associated with developmental coordination disorder are not attributable to macrostructural brain abnormalities, but differences in brain microstructure may exist. Using diffusion tensor imaging, we explored the integrity of motor, sensory, and cerebellar pathways in children with and without developmental coordination disorder. In seven children with the disorder and nine typically developing children (aged 8-12 years), we measured diffusivity and fractional anisotropy of the corticospinal tract, posterior thalamic radiation, and superior and middle cerebellar peduncles. Fractional anisotropy of motor and sensory tracts and diffusion parameters in cerebellar peduncles did not differ between groups. Mean diffusivity of the corticospinal tract and posterior thalamic radiation was lower in children with developmental coordination disorder compared with control children (P < 0.04 and P < 0.06, respectively). Results were driven by lower axial diffusivity, which was significantly correlated with motor impairment scores on the Movement Assessment Battery for Children-2 for both the corticospinal tract (r = 0.56, P = 0.03) and posterior thalamic radiation (r = 0.70, P = 0.003). Reduced axial diffusivity in motor and se...Continue Reading

Associated Clinical Trials

Nov 5, 2015·Jill Zwicker
Oct 8, 2019·Jill Zwicker
Jul 23, 2020·Jill Zwicker

References

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Aug 19, 2009·Journal of Child Neurology·Jill G ZwickerLara A Boyd
Sep 5, 2009·Neuroreport·Mitsuru KashiwagiShuhei Suzuki
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Dec 15, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jill G ZwickerLara A Boyd

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Citations

Oct 8, 2014·Acta Neuropsychiatrica·Stephanie H AmeisEvdokia Anagnostou
Oct 15, 2013·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Jorrit F de KievietJaap Oosterlaan
Nov 4, 2015·The Journal of Pediatrics·Julie DebrabantKaren Caeyenberghs
Jun 19, 2012·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Jill G ZwickerLara A Boyd
Jan 15, 2016·Brain & Development·Marie FarmerM'hamed Bentourkia
Nov 28, 2013·Developmental Medicine and Child Neurology·Lieke H J PetersMijna Hadders-Algra
Apr 7, 2015·Human Movement Science·Bouwien Smits-EngelsmanReint Geuze
Mar 1, 2014·The Journal of Pediatrics·Lisa Marie LangevinDeborah Dewey
Jan 26, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jess E ReynoldsJac Billington
Dec 18, 2019·Child: Care, Health and Development·Rodrigo Flores SartoriRochele Paz Fonseca
Aug 29, 2020·Developmental Medicine and Child Neurology·Laurence Vaivre-Douret
Dec 27, 2016·Frontiers in Neurology·Maëlle BiotteauJean-Michel Albaret
Jan 30, 2019·Frontiers in Integrative Neuroscience·Annie Brandes-AitkenElysa J Marco
Jan 26, 2017·Frontiers in Human Neuroscience·Giovanni MirabellaFlavia Capozzi
Mar 3, 2018·Current Developmental Disorders Reports·Dido Green, Sally Payne
Jun 22, 2021·Frontiers in Human Neuroscience·Sara Izadi-Najafabadi, Jill G Zwicker

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