Developmental Coordination during Olfactory Circuit Remodeling in Drosophila

Neuron
Oded MayselessOren Schuldiner

Abstract

Developmental neuronal remodeling is crucial for proper wiring of the adult nervous system. While remodeling of individual neuronal populations has been studied, how neuronal circuits remodel-and whether remodeling of synaptic partners is coordinated-is unknown. We found that the Drosophila anterior paired lateral (APL) neuron undergoes stereotypic remodeling during metamorphosis in a similar time frame as the mushroom body (MB) ɣ-neurons, with whom it forms a functional circuit. By simultaneously manipulating both neuronal populations, we found that cell-autonomous inhibition of ɣ-neuron pruning resulted in the inhibition of APL pruning in a process that is mediated, at least in part, by Ca2+-Calmodulin and neuronal activity dependent interaction. Finally, ectopic unpruned MB ɣ axons display ectopic connections with the APL, as well as with other neurons, at the adult, suggesting that inhibiting remodeling of one neuronal type can affect the functional wiring of the entire micro-circuit.

Citations

Jul 1, 2020·Proceedings of the National Academy of Sciences of the United States of America·Anthi A Apostolopoulou, Andrew C Lin
Sep 22, 2020·ELife·Hoger AminAndrew C Lin
Jan 7, 2021·Cell and Tissue Research·Vanessa M PuñalE Josephine Clowney
Mar 25, 2021·Proceedings. Biological Sciences·Cheyenne TaitShannon B Olsson
Apr 30, 2021·Journal of Cell Science·Pawel MozolewskiRadek Dobrowolski
May 11, 2021·Frontiers in Behavioral Neuroscience·Rebecca R Westwick, Clare C Rittschof

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