Developmental delay and unstable state of the testes in the rdw rat with congenital hypothyroidism

Development, Growth & Differentiation
Yasuhiro SakaiS Furudate

Abstract

From the present study of the rdw rat, it is clear that the thyroid hormone is essential for the development and maintenance of the testes. In previous studies, the thyroid hormone has few serious effects on the testes except during the neonatal stage when the thyroid hormone receptor is mainly present. However, there is little knowledge concerning the prolonged effect of thyroid hormone deficiency throughout the rat's life span. In the present study, a morphological analysis was performed on the testes of rdw rats with congenital hypothyroidism. The rdw testes required a longer time to develop into the normal adult structure. Moreover, the developed, normal structure began to degenerate after full maturation. Specific characteristics of the rdw testes include: (i) a prolonged proliferation of Sertoli cells during postnatal development; (ii) a developmental delay in the appearance of spermatocytes and spermatid; (iii) direct contact with each other for both spermatocytes and spermatids, without Sertoli cell cytoplasm completely intervening between adjacent germ cells; (iv) subsequent apoptosis of germ cells after maturation; (v) reduction in the height of the seminiferous epithelium; and (vi) lower testosterone levels in the rd...Continue Reading

References

Jan 1, 1988·Jikken dobutsu. Experimental animals·M KotoJ Adachi
Mar 10, 2000·Journal of Endocrinological Investigation·E A JanniniM D'Armiento

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Citations

Aug 30, 2008·The Journal of Endocrinology·Márcia Santos WagnerAna Luiza Maia
Sep 27, 2012·Cellular and Molecular Life Sciences : CMLS·Marco G AlvesPedro F Oliveira
Aug 31, 2011·General and Comparative Endocrinology·Wafaa IbrahimMohammed A Mansour
Aug 4, 2010·General and Comparative Endocrinology·Sutapa ChattopadhyayLuna Samanta
Jul 29, 2009·Microscopy Research and Technique·Marcia Santos WagnerAna Luiza Maia
Aug 7, 2017·Animal Science Journal = Nihon Chikusan Gakkaihō·Mohamed Babo FadlallaFangxiong Shi
Nov 14, 2014·The Journal of Toxicological Sciences·Kenichi KobayashiMuneyuki Miyagawa
Oct 13, 2019·Molecular and Cellular Endocrinology·Yoshiaki Morishita, Peter Arvan

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