PMID: 16508388Mar 2, 2006Paper

Developmental differences in spinal cyclooxygenase 1 expression after surgical incision

Anesthesiology
Douglas G RirieJames C Eisenach

Abstract

Systemic administration of a cyclooxygenase 1 (COX-1) inhibitor reduces hypersensitivity to mechanical stimuli after incisional paw surgery in 4-week-old, but not 2-week-old, animals. The purpose of the current study was to test whether this developmental difference was reflected by differences in COX-1 expression in the spinal cord after surgery. Rats 2 and 4 weeks of age, paralleling infant and child human neurologic developmental stages, were used. A paw incision was made under general anesthesia and the withdrawal thresholds were measured before and after systemic and intrathecal administration of a COX-1 selective inhibitor (SC560). Immunohistochemistry was used to assess COX-1 protein in the spinal cord, and real-time polymerase chain reaction was used to quantify gene expression of COX-1 mRNA. Systemic and intrathecal administration of SC560 produced an increase in withdrawal threshold in the 4-week-old, but not in the 2-week-old, animals. Intrathecal SC560 increased withdrawal thresholds in the 4-week-old animals at a dose 100-fold less than with systemic administration. Cyclooxygenase 1 protein in the spinal cord was increased ipsilateral to surgery in the 4-week-old, but not in the 2-week-old, animals. Cyclooxygenase ...Continue Reading

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Citations

Jan 9, 2009·Nature Clinical Practice. Neurology·Maria Fitzgerald, Suellen M Walker
Oct 11, 2012·International Anesthesiology Clinics·Vidya Chidambaran, Senthilkumar Sadhasivam
Sep 11, 2014·Developmental Neurobiology·Deirtra HunterGordon A Barr
Jun 10, 2014·Developmental Psychobiology·Gordon A Barr, Deirtra A Hunter
Oct 1, 2019·European Journal of Pain : EJP·Daniel SegelckeEsther M Pogatzki-Zahn

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