Developmental differences in the accumbal dopaminergic response to repeated ethanol exposure

Annals of the New York Academy of Sciences
Rex M Philpot, Cheryl L Kirstein

Abstract

Recent research indicates that alcohol use/abuse is often initiated during the adolescent period and that brain reinforcement pathways (e.g., the mesolimbic dopamine [DA] pathway) are undergoing developmental transition. Our research focuses on the effects of ethanol administration on neural mechanisms associated with addiction in preadolescent (postnatal day [PND] 25), adolescent (PND 35, PND 45), and young adult (PND 60) animals. Using conditioned place preference (CPP) testing, we have shown that adolescent animals are unique in their responses to ethanol. Since CPP has been associated with contextually conditioned incentive motivation, our results suggest that younger animals may be more vulnerable to addiction. The present data reveal that adolescent animals are neurochemically distinct in response to ethanol's effects. Using in vivo microdialysis within the nucleus accumbens septi (NAcc), we have determined the DAergic response across development. Results reveal that basal levels of DA transition during the adolescent period and differ from preadolescent or adult animals. Specifically, PND 45 animals exhibited significantly higher, and PND 25 significantly lower, basal DA levels than all other ages examined. Further, repe...Continue Reading

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Citations

Mar 13, 2010·Current Opinion in Psychiatry·Kimberly Nixon, Justin A McClain
Sep 17, 2005·Journal of Psychopharmacology·Briony J Catlow, Cheryl L Kirstein
Feb 2, 2013·Endocrinology·Margaret R Bell, Cheryl L Sisk
Nov 13, 2013·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·María PascualConsuelo Guerri
Feb 2, 2010·Alcohol·Antoniette M Maldonado-DevincciCheryl L Kirstein
Aug 29, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Rex M PhilpotCheryl L Kirstein
Oct 23, 2008·Pharmacology, Biochemistry, and Behavior·Brendan M Walker, Cindy L Ehlers
Jul 5, 2008·Brain Research Bulletin·E ShearmanA Lajtha
Dec 23, 2006·Neurotoxicology and Teratology·Briony J Catlow, Cheryl L Kirstein
Oct 24, 2007·Alcoholism, Clinical and Experimental Research·Mei SongLin Lu
Mar 30, 2007·Alcoholism, Clinical and Experimental Research·Kimberly A BadanichCheryl L Kirstein
Dec 14, 2005·Brain Research·Jörg LestingGertraud Teuchert-Noodt
Jul 18, 2006·Pharmacology, Biochemistry, and Behavior·Danielle L Graham, Jaime L Diaz-Granados
Jun 9, 2006·Peptides·Kelly Philpot, Yoland Smith
Sep 30, 2016·Pharmacological Reviews·Fulton T CrewsDonita L Robinson
Dec 17, 2009·Neurochemical Research·A Lajtha, H Sershen
Jun 24, 2017·Molecular Brain·Robert NisticòStephane Peineau
Feb 15, 2017·Alcoholism, Clinical and Experimental Research·Aric C MadayagDonita L Robinson

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