PMID: 6110194Aug 1, 1980Paper

Developmental dissociation of myelin synthesis and "myelin-associated" enzyme activities in the shiverer mouse

Neurochemical Research
T D BirdE Austin

Abstract

Developmental changes in three enzymes associated with myelin lipids were studied in the shiverer mouse, a murine mutant showing a severe deficiency of CNS myelin. Age-related changes in cerebroside sulfotransferase (measured in brain) and arylsulfatase A and cerebroside B-galactosidase (measured in brain and liver) were the same for shiverer and control mice. The shiverer mouse, therefore, demonstrates a dissociation between the genetic mechanisms regulating myelination in the CNS and developmental changes in enzyme activities thought to be closely related to the synthesis of myelin. In addition, we found no defect in the shiverer mouse in the incorporation of glycine-labeled basic protein into CNS myelin, indicating an important metabolic difference between the morphologically similar shiverer and quaking mutants.

References

Jan 1, 1977·Neuroscience·T BurkartN N Herschkowitz
Jun 1, 1979·Journal of Neurochemistry·S GreenfieldE L Hogan
Oct 1, 1973·Journal of Neurochemistry·W T Norton, S E Poduslo
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Citations

Aug 1, 1982·Journal of Neurocytology·M P DentingerC K Csiza
Mar 1, 1984·Journal of Neurochemistry·A T CampagnoniN Baumann
Dec 7, 2018·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Rajanikanth J MagantiPeter Juhasz

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