Abstract
Developmental changes in three enzymes associated with myelin lipids were studied in the shiverer mouse, a murine mutant showing a severe deficiency of CNS myelin. Age-related changes in cerebroside sulfotransferase (measured in brain) and arylsulfatase A and cerebroside B-galactosidase (measured in brain and liver) were the same for shiverer and control mice. The shiverer mouse, therefore, demonstrates a dissociation between the genetic mechanisms regulating myelination in the CNS and developmental changes in enzyme activities thought to be closely related to the synthesis of myelin. In addition, we found no defect in the shiverer mouse in the incorporation of glycine-labeled basic protein into CNS myelin, indicating an important metabolic difference between the morphologically similar shiverer and quaking mutants.
References
Jan 1, 1977·Neuroscience·T BurkartN N Herschkowitz
Apr 1, 1979·Neuroscience Letters·P DupoueyN Baumann
Jun 1, 1979·Journal of Neurochemistry·S GreenfieldE L Hogan
Jul 1, 1978·Journal of Neurochemistry·T D BirdS M Sumi
Jan 28, 1977·Brain Research·S GreenfieldE Hogan
Jan 28, 1977·Brain Research·S W BrostoffE L Hogan
Jan 1, 1976·Analytical Biochemistry·G Baumann, A Chrambach
Oct 1, 1973·Journal of Neurochemistry·W T Norton, S E Poduslo
Jul 1, 1970·Journal of Neurochemistry·F Gonzalez-Sastre
Jul 1, 1970·Journal of Neurochemistry·T KuriharaP Mandel
Dec 13, 1974·Brain Research·B ZalcN A Baumann
Jan 1, 1972·Preparative Biochemistry·G E DeiblerM W Kies
Jul 1, 1974·Journal of Neurochemistry·D F Farrell
Apr 1, 1972·Lipids·J Kanfer, M Stein
Nov 1, 1971·Journal of Neurochemistry·S GreenfieldP Morell
May 1, 1971·Journal of Neurochemistry·J A BenjaminsG M McKhann
Apr 10, 1970·Science·D J Kurtz, J N Kanfer
Jun 30, 1970·Brain Research·N NeskovicP Mandel
Mar 1, 1969·Journal of Neurochemistry·D M Bowen, N S Radin
Jul 1, 1967·Journal of Neurochemistry·G M McKhann, W Ho
Dec 1, 1976·Neuroscience·L L SarlieveP Mandel
Dec 1, 1971·FEBS Letters·L L. SarlieveP Mandel
Citations
Aug 1, 1982·Journal of Neurocytology·M P DentingerC K Csiza
Feb 1, 1986·Neurochemical Pathology·J M BourreJ Viret
Jun 1, 1984·Journal of Neurochemistry·L HofK D Barron
Mar 1, 1984·Journal of Neurochemistry·A T CampagnoniN Baumann
Dec 7, 2018·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Rajanikanth J MagantiPeter Juhasz