Developmental effects of dioxins

Environmental Health Perspectives
L S Birnbaum

Abstract

The potent developmental toxicity of dioxin in multiple species has been known for a number of years. However, recent studies have indicated that dioxin also induces functional developmental defects, many of which are delayed. Subtle structural deficits, not detectable at birth, have also been described in multiple species and in both sexes. Certain defects have been reported not only in animals but also in children prenatally exposed to complex mixtures containing dioxinlike compounds. None of the effects can be attributed to modulation of any one endocrine system. For example, dioxin does not bind to the estrogen receptor, but it can cause effects that are both estrogenic and antiestrogenic. However, viewing dioxin and related compounds as endocrine disruptors that may alter multiple pathways sheds some light on the complexities of this potent class of growth dysregulators.

References

Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·D A PeattieM Benasutti
Nov 30, 1992·Biochemical and Biophysical Research Communications·X MaJ G Babish
Apr 15, 1992·Biochemical and Biophysical Research Communications·M EmaY Fujii-Kuriyama
Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·K M BurbachC A Bradfield
Dec 9, 1992·JAMA : the Journal of the American Medical Association·Y C ChenW J Rogan
Feb 1, 1992·Toxicology and Applied Pharmacology·B L BlaylockM I Luster
Dec 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P J Fuller
Jan 1, 1990·Annual Review of Pharmacology and Toxicology·J P Whitlock
Jul 1, 1990·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·L A CoutureL S Birnbaum
May 1, 1989·Toxicology and Applied Pharmacology·L S BirnbaumR E Morrissey
Jun 15, 1989·Toxicology and Applied Pharmacology·B D Abbott, L S Birnbaum
Jun 15, 1989·Toxicology and Applied Pharmacology·B D Abbott, L S Birnbaum
Aug 1, 1989·Toxicology and Applied Pharmacology·B D AbbottL S Birnbaum
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D W BombickF Matsumura
Feb 1, 1985·Environmental Health Perspectives·S T HsuS B Wu
Jun 15, 1985·Toxicology and Applied Pharmacology·R W MooreR E Peterson
Jun 1, 1981·Biulleten' eksperimental'noĭ biologii i meditsiny·A G MelikiantsA G Malenkov
Sep 1, 1995·Toxicology·M J DeVito, L S Birnbaum
May 1, 1995·Reproductive Toxicology·A M Cummings, J L Metcalf
Nov 1, 1994·Environmental Health Perspectives·L S Birnbaum
Nov 1, 1994·Chemosphere·T J LaiC C Hsu

❮ Previous
Next ❯

Citations

May 26, 1998·Environmental Health Perspectives·J A GrassmanG W Lucier
Jun 16, 2000·Environmental Health Perspectives·S H Safe
Jul 9, 2004·Toxicology and Applied Pharmacology·Vincent F Garry
Jul 20, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·J A Shelby, M T Mendonça
Oct 18, 2000·Toxicology in Vitro : an International Journal Published in Association with BIBRA·S PawlowskiT Braunbeck
Jul 10, 2002·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·M IslingerT Braunbeck
Oct 25, 2011·Chemosphere·Andrea ColomboRoberto Fanelli
Aug 5, 2009·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Jennifer A Shelby-WalkerMary T Mendonça
Sep 1, 2009·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Cheng-hao LiBing Shi
Jul 22, 2006·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Nadzieja Drela
Jan 4, 2005·Biochemical Pharmacology·Alvaro PugaYing Xia
Sep 12, 2006·Biochimica Et Biophysica Acta·Jennifer A SchwanekampCraig R Tomlinson
May 29, 2002·General and Comparative Endocrinology·Joël RousseauMaria-Grazia Martinoli
May 17, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Jessica A ThornleyCraig R Tomlinson
Nov 13, 2012·Chemosphere·Andrea ColomboRoberto Fanelli
Aug 26, 2014·The Science of the Total Environment·Andrea ColomboPaolo Galli
Jun 14, 2016·Environmental Research·Lai Ling HuiRichard Fielding
Sep 29, 2000·Biochemical Pharmacology·A PugaM Medvedovic
Mar 10, 2001·American Journal of Public Health·UNKNOWN American Public Health Association
Mar 10, 2001·American Journal of Public Health·UNKNOWN American Public Health Association
Mar 10, 2001·American Journal of Public Health·UNKNOWN American Public Health Association
Mar 10, 2001·American Journal of Public Health·UNKNOWN American Public Health Association
Mar 10, 2001·American Journal of Public Health·UNKNOWN American Public Health Association
Mar 10, 2001·American Journal of Public Health·UNKNOWN American Public Health Association
Mar 10, 2001·American Journal of Public Health·UNKNOWN American Public Health Association
Mar 10, 2001·American Journal of Public Health·UNKNOWN American Public Health Association
Mar 10, 2001·American Journal of Public Health·UNKNOWN American Public Health Association
Mar 10, 2001·American Journal of Public Health·UNKNOWN American Public Health Association
Mar 10, 2001·American Journal of Public Health·UNKNOWN American Public Health Association
Mar 10, 2001·American Journal of Public Health·UNKNOWN American Public Health Association
Mar 10, 2001·American Journal of Public Health·UNKNOWN American Public Health Association

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.