PMID: 15222401Jun 30, 2004Paper

Developmental effects of propyphenazone in analgesic and antipyretic combination with caffeine or paracetamol

Human & Experimental Toxicology
F Burdan

Abstract

The aim of the study was to determine the influence of an over-the-counter (OTC) mixture of propyphenazone with caffeine or paracetamol on prenatal development. Propyphenazone:caffeine and propyphenazone:paracetamol mixtures were prepared with constant 3:1 and 3:5 ratios, respectively. Three dose levels of each of the mixtures were administered separately in Tween-80 water suspension once a day to pregnant Wistar rats on gestation days 8-14. The low dose was similar to the OTC preparations, 2.1 mg/kg of propyphenazone, 0.7 mg/kg of caffeine or 3.5 mg/kg of paracetamol. The middle dose was 21.0, 7.0 or 35.0 mg/kg, and the highest 210.0, 70.0 or 350.0 mg/kg for propyphenazone, caffeine or paracetamol, respectively. On day 21 of gestation the fetuses were delivered by hysterectomy. Dead or live fetuses, resorptions and the number of implantation sites were counted. Live fetuses were examined for external, visceral and skeletal malformation. Postimplantation mortality was calculated. Dose-dependent effects in the middle and high dose groups on fetal body weight/length and placental weight were found. No increase in external or internal congenital anomalies was found in any of the mixture-exposed groups. Prenatal coadministration of...Continue Reading

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Citations

Sep 17, 2009·Pediatric Surgery International·Dennis R Van DorpMichael D Klein
Jul 21, 2012·Pharmacological Reports : PR·Franciszek BurdanJustyna Szumiło
Feb 26, 2013·Journal of Reproductive Immunology·Kristin ThieleGisa Tiegs
Sep 15, 2015·Toxicology and Applied Pharmacology·Yi-Meng WuHui Wang
Jun 18, 2009·Journal of Applied Toxicology : JAT·A David, K Pancharatna
Mar 4, 2011·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Robert L BrentRobert M Diener
Jul 25, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F BurdanR Klepacz
Oct 27, 2004·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Franciszek Burdan

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