Developmental exposure to heavy metals alters visually-guided behaviors in zebrafish

Current Zoology
Matthew K LeFauve, Victoria P Connaughton

Abstract

This laboratory-based study determined the consequences of heavy metal exposure using zebrafishDanio rerio. Embryos were transiently exposed to environmentally-relevant concentrations of cadmium or nickel until 72 h postfertilization (hpf), then they were returned to system water and allowed to grow until 7, 9, and 11 days postfertilization (dpf), when they were examined morphologically and behaviorally. Morphological measures of notochord length, eye diameter, and inter-eye distance were not different across treatments; however, significant differences in optomotor responses were observed in treated larvae at all ages tested. These results suggest that initial developmental exposure to cadmium and nickel significantly impacts visually-guided larval behavior. The absence of significant differences in gross morphology suggests that the effects of these metals are subtle and may occur at the cellular level. By using this ecologically relevant model and pollutant type, this study has broad application and implications with regard to safe levels of contaminant in drinking water and freshwater ecosystems.

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Citations

May 6, 2019·Cellular and Molecular Life Sciences : CMLS·Zsófia RakvácsGergely Szakács
Feb 2, 2020·Archives of Environmental Contamination and Toxicology·Rebecca L WilkenVictoria P Connaughton
Jun 9, 2020·Environmental Science and Pollution Research International·Mohamed Lamine SallJean-Jacques Aaron
Oct 25, 2020·The European Journal of Neuroscience·Giovanni AnnonaMarina Paolucci
Nov 6, 2017·The Science of the Total Environment·Débora Dreher NabingerCarla Denise Bonan
Mar 2, 2021·Journal of Applied Toxicology : JAT·Yongmeng YangYuanqing Bu
May 1, 2021·Journal of Developmental Biology·Mikayla Crowley-PerryVictoria P Connaughton

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