Developmental exposure to organophosphate flame retardants causes behavioral effects in larval and adult zebrafish

Neurotoxicology and Teratology
A N OliveriEdward D Levin

Abstract

Organophosphate flame retardants (OPFRs) have grown in usage since concerns about the health effects of the previously used polybrominated flame retardants led to their being phased out. The potential for OPFRs to cause adverse health effects of their own is still unexamined. Because of their structural similarities to organophosphate pesticides, which have themselves been heavily researched and shown to be neurobehavioral teratogens, we investigated the possibility that developmental exposure to two OPFRs, triphenyl phosphate (TPHP), and tris(1,3-dichloroisopropyl)phosphate (TDCIPP) might lead to behavioral impairment across the lifespan, as has been observed with the organophosphate pesticide chlorpyrifos. Zebrafish were exposed to 0.03 or 0.3 μM of TPHP, TDCIPP, or chlorpyrifos from 0 to 5 days post fertilization. Vehicle control consisted of 0.03% solution of DMSO. At 6 days post fertilization, larvae were tested on a locomotor assay. Separate cohorts of 6 day old larvae that were not tested on the larval assay were allowed to grow to adulthood. At 12 weeks post fertilization, these adult zebrafish were tested on a battery of behavioral assays that included tests of novel environment exploration, startle habituation, social...Continue Reading

References

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Citations

Jan 18, 2016·Chemosphere·Erika D SchrederMark J La Guardia
Sep 13, 2015·Neurotoxicology and Teratology·Hester S Hendriks, Remco H S Westerink
Jun 17, 2016·Environmental Science & Technology·Roxana SühringLiisa M Jantunen
Jul 10, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lilah GlazerEdward D Levin
Nov 23, 2019·Current Environmental Health Reports·Brett T DohertyKate Hoffman
May 22, 2020·Environmental Geochemistry and Health·Chijioke Olisah, Janine B Adams
Oct 20, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Joey S StevensAimen K Farraj
Aug 16, 2019·Disease Models & Mechanisms·Yijie Geng, Randall T Peterson
Aug 28, 2020·Neurotoxicology and Teratology·Mathan RameshSathisaran Umamaheswari
Jun 5, 2020·Environmental Science & Technology Letters·Arlene BlumMarta Venier
Oct 7, 2021·Environmental Health Perspectives·Heather B PatisaulHeather M Stapleton

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