Developmental expression and function analysis of protein tyrosine phosphatase receptor type D in oligodendrocyte myelination

Neuroscience
Q ZhuMengsheng Qiu

Abstract

Receptor protein tyrosine phosphatases (RPTPs) are extensively expressed in the central nervous system (CNS), and have distinct spatial and temporal patterns in different cell types during development. Previous studies have demonstrated possible roles for RPTPs in axon outgrowth, guidance, and synaptogenesis. In the present study, our results revealed that protein tyrosine phosphatase, receptor type D (PTPRD) was initially expressed in mature neurons in embryonic CNS, and later in oligodendroglial cells at postnatal stages when oligodendrocytes undergo active axonal myelination process. In PTPRD mutants, oligodendrocyte differentiation was normal and a transient myelination delay occurred at early postnatal stages, indicating the contribution of PTPRD to the initiation of axonal myelination. Our results also showed that the remyelination process was not affected in the absence of PTPRD function after a cuprizone-induced demyelination in adult animals.

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Citations

Jan 28, 2017·Journal of Alzheimer's Disease : JAD·Raffaele FerrariBarbara Borroni
Jan 17, 2019·Annals of the New York Academy of Sciences·George R Uhl, Maria J Martinez
Sep 25, 2019·Genome Research·Abigail F GroffKevin Eggan

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