Developmental expression and regulation of the gap junction protein and transcript in rat ovaries

Molecular Reproduction and Development
I Granot, N Dekel

Abstract

The extensively developed network of cell-to-cell communication, generated by gap junctions, mediates transmission of small molecules between the cells of the ovarian follicle. Our study aimed at the analysis of the ontogeny and regulation of connexin43 (Cx43) the ovarian gap junction protein and its gene expression throughout folliculogenesis. Developmental analysis was performed using ovaries of immature rats at different ages and selected ovarian follicles of sexually mature female rats at different phases of their estrous cycle. In order to establish the effect of hormones involved in regulation of folliculogenesis on Cx43 modulation, the experimental animal model of sexually immature female rats administered with exogenous gonadotropins was employed. Developmental and hormonal modulations of Cx43 protein and its mRNA expression were studied by Western and Northern blot analysis, respectively. We found that Cx43 was undetectable in ovaries of rats on the first postnatal day, with a low level of this protein observed in 11-day-old rats ovaries. Some increase in the amount of Cx43 was observed at the age of 25 days with a dramatic elevation accompanied by phosphorylation of this protein that was specific to large antral folli...Continue Reading

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Citations

Dec 22, 1999·Molecular Reproduction and Development·J ZhaoR Van Den Hurk
Feb 15, 2001·Molecular Reproduction and Development·J ZhaoR Van Den Hurk
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Aug 7, 2002·Trends in Endocrinology and Metabolism : TEM·Irit Granot, Nava Dekel
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