PMID: 1473278Nov 20, 1992

Developmental expression of brain derived neurotrophic factor mRNA by neurons of fetal and adult monkey prefrontal cortex

Brain Research. Developmental Brain Research
G W HuntleyP J Isackson


In situ hybridization histochemistry with labeled cRNA probes complementary to monkey brain derived neurotrophic factor (BDNF) mRNAs has been used to study the cellular localization and expression of this neurotrophin in the prefrontal cerebral cortex of fetal and adult monkeys. Expression could not be detected in prefrontal cortex before the 121st fetal day. Thereafter, in fetal life and in adulthood BDNF mRNA could be detected primarily in large, putative pyramidal cells of layers III and VI throughout the prefrontal cortex. The temporal course and cellular localization of BDNF expression suggests its association with the development and stabilization of specific connections in regions of cortex that display marked functional plasticity.


Oct 15, 1977·The Journal of Comparative Neurology·E G Jones, S P Wise
May 1, 1991·The Journal of Comparative Neurology·M L Schwartz, P S Goldman-Rakic
May 1, 1991·Trends in Neurosciences·H Thoenen
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D E Pellegrini-GiampietroR S Zukin
Jan 1, 1990·Experimental Brain Research·G W HuntleyE G Jones
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K L AllendoerferC J Shatz
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K R Jones, L F Reichardt
Mar 23, 1990·Science·P C MaisonpierreG D Yancopoulos
Jan 1, 1989·Brain Research. Developmental Brain Research·A YamashitaK Oshima
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P S Goldman-RakicM Geffard
Oct 1, 1989·Annals of Neurology·W D Snider, E M Johnson
Jul 8, 1988·Science·P Rakic
Jun 15, 1988·The Journal of Comparative Neurology·R W Williams, P Rakic
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J A Kessler, I B Black
Dec 1, 1984·Archives of General Psychiatry·M S BuchsbaumJ Morihisa
Jul 30, 1982·Science·R T BartusA S Lippa
Jul 1, 1991·The European Journal of Neuroscience·Wilma J. FriedmanHåkan Persson


May 17, 2000·The Journal of Comparative Neurology·J Z Barlow, G W Huntley
Jun 26, 1998·Brain Research. Brain Research Reviews·B Connor, M Dragunow
Dec 14, 2002·Brain Research. Developmental Brain Research·Maree J WebsterJ E Kleinman
Oct 19, 2002·Behavioural Brain Research·David M LyonsMichael E Moseley
Dec 5, 1997·Brain Research. Molecular Brain Research·B ConnorM Dragunow
Mar 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kazuko SakataBai Lu
Apr 30, 2008·BMC Neuroscience·Yan JiangSchahram Akbarian
May 18, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shau-Ming WeiKaren F Berman
Jan 18, 2005·Biological Psychiatry·Ruth A Carper, Eric Courchesne
Jan 13, 2006·Journal of Neurobiology·Maribel RiosGeorge K Aghajanian
Jun 25, 2013·Neuropharmacology·Elke EdelmannTanja Brigadski
Nov 13, 2004·Neuroreport·Takuma MoriMotoharu Hayashi
Apr 4, 2000·The Journal of Comparative Neurology·E S LeinC J Shatz
Jun 20, 2002·Bipolar Disorders·Grazyna Rajkowska
Oct 31, 2002·Human Psychopharmacology·M Sandler
Aug 11, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Hong-Tian ZhangTim Ting-Hua Wang
Jul 1, 1996·Neurochemical Research·M Hayashi
Sep 1, 1997·Pediatric Surgery International·D L CassN S Adzick
Jul 1, 1997·Reviews in the Neurosciences·M DragunowR L Faull

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