Developmental expression of calmodulin mRNA and protein in regions of the postnatal rat brain

Journal of Neuroscience Research
F Berry, I R Brown

Abstract

The expression of calmodulin (CaM) protein and mRNA was analyzed in specific regions of the rat brain during postnatal development. CaM levels in the adult brain were more abundant in the cerebral hemispheres and thalamus compared to brain stem and superior plus inferior colliculus. All brain regions contained higher CaM protein and mRNA levels than in non-neural tissues such as the kidney. During postnatal development of the brain, maximal levels of CaM protein and CaM I mRNAs were attained at day 10 or 15. Protein levels declined thereafter in the adult in all regions except the thalamus. With respect to products of the rat CaM I gene, the 4.0 kb neural transcript demonstrated a pronounced increase during postnatal development, whereas the 1.8 kb message showed little change.

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Citations

Mar 1, 1996·Journal of Neuroscience Research·F B Berry, I R Brown
Sep 25, 2002·Life Sciences·Arpad PalfiKaroly Gulya
Sep 3, 2002·Neuroscience·E KortvelyK Gulya
Nov 26, 2002·Biochimica Et Biophysica Acta·Sonja L Toutenhoofd, Emanuel E Strehler
Mar 11, 2004·Journal of Neurochemistry·Pascal E D Lachance, Avi Chaudhuri
Oct 8, 2013·The Journal of Comparative Neurology·Marco GymnopoulosMartin Stocker
Aug 13, 2005·Brain Research. Developmental Brain Research·Boris DecourtAziz Hafidi
Jul 30, 2005·Brain Research. Developmental Brain Research·Boris DecourtAziz Hafidi
Mar 19, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Elod KortvelyKaroly Gulya

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