Developmental expression of chemokine-like factor 1, a novel member of chemokines family, in postnatal rat cerebral cortex

Neuroscience Letters
Zhen Zhen WangNai Hong Chen

Abstract

Chemokine-like factor 1 (CKLF1) has been implicated to induce the migration of neuroblastoma cells and is abundant in fetal brain but scarce in adult brain. Given the importance of neural cell migration in brain development, it is possible that the chemotaxis of CKLF1 is required during brain development. Therefore, it is essential to know the detailed expression profiles of CKLF1 during brain development first. However, the developmental expression patterns of CKLF1 still remain unclear. We aimed to investigate the temporal and spatial expressions of CKLF1 during cerebral cortex postnatal development in rats. By reverse-transcription PCR/immunoblotting at multiple time points, the mRNA/protein expressions of CKLF1 were in abundance at birth, then decreased progressively within the next two weeks and almost disappeared in adulthood. By immunohistochemistry staining, an obvious expression of CKLF1 was observed in the cerebral cortex, hippocampus, olfactory bulb, some specific nuclei and commissural fibers. Concluding, the temporal expression pattern of CKLF1 was coincident with the postnatal developmental stages and the spatial locations of CKLF1 were some destinations of neural cell migration or regions where myelination normal...Continue Reading

References

Jan 28, 1998·Journal of the American Academy of Child and Adolescent Psychiatry·P Rakic, P J Lombroso
Aug 24, 1999·Journal of Neurobiology·A Rodríguez-Peña
Jan 25, 2002·Annual Review of Pharmacology and Toxicology·Elias J Fernandez, Elias Lolis
Sep 7, 2002·Science·Mary E Hatten
Feb 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kim T Nguyen-Ba-CharvetAlain Chédotal
May 1, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Masahiro SuganoNaoki Makino
Aug 17, 2005·Current Drug Targets. Inflammation and Allergy·Ghazal BanisadrStéphane Mélik Parsadaniantz
Jan 13, 2006·British Journal of Pharmacology·James E Pease, Timothy J Williams
Mar 17, 2007·Journal of Neuroimmunology·Lucy VulchanovaDavid R Brown
Dec 7, 2007·Nature Neuroscience·Gang ChenXiao-Bing Yuan
Nov 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christine MétinPradeep G Bhide
Dec 18, 2008·The European Journal of Neuroscience·Jean-Marc Fritschy
Jan 6, 2009·Acta Paediatrica·Alberto SpalicePaola Iannetti
Feb 28, 2009·Neurobiology of Disease·Renzo Guerrini, Elena Parrini
Mar 7, 2009·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Alberto VerrottiPaola Iannetti
May 12, 2009·Progress in Neurobiology·Myriam CayreJames E Goldman
Jul 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mirjam SibbeMichael Frotscher
Jun 23, 2011·Annual Review of Neuroscience·Stephen P J FancyDavid H Rowitch
Oct 4, 2011·Neuroscience Letters·Ling-Lei KongNai-Hong Chen
Dec 29, 2015·Biochemical Pharmacology·Elena FerriCharles E McKenna

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