Developmental expression of Dkk1-3 and Mmp9 and apoptosis in cranial base of mice

Journal of Molecular Histology
Xuguang NiePäivi Kettunen

Abstract

The Dickkopf (Dkk) family and Mmp9 are important for apoptosis and a number of other developmental processes. However, little is known about their roles in the development of cranial base, which is an important structure for coordinated development and growth of the craniofacial skeletons. In order to establish whether and in what way these genes are involved in cranial base development, we examined their expression patterns and cell apoptosis. Dkk1 was first seen in the perichondral mesenchyme in restricted domains from E14, and later in the migrating mesenchymal cells within the cartilage. Thereafter, it was widespread throughout the bones of the cranial base. The expression was downregulated in postnatal stages. Dkk2 was localized in the perichondral mesenchyme outlining the anterior cranial base in embryogenesis. Dkk3 was mainly detected in the occipital-vertebral joint at E13 and E14. Mmp9 transcripts were clustered in the inner layer of perichondral mesenchyme, juxtaposed with the terminally differentiated hypertrophic chondrocytes from E14. Later Mmp9-expressing cells were found at the sites of chondrocyte apoptosis. This was particularly clear at the distal ends of the synchondroses. These data indicate that Mmp9 regula...Continue Reading

References

Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Nov 1, 1993·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·K MølstedE Dahl
Jul 1, 1993·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·S KreiborgM W Vannier
Jun 1, 1996·European Journal of Orthodontics·M MidtbøA Halse
Apr 1, 1997·Plastic and Reconstructive Surgery·P RosenbergG LaTrenta
Feb 25, 1999·Cranio : the Journal of Craniomandibular Practice·R A HilloowalaR G Pifer
Sep 24, 1999·Mechanisms of Development·A P MonaghanC Niehrs
May 24, 2000·European Journal of Orthodontics·E AndersenI Kjaer
Nov 13, 2001·Developmental Cell·M MukhopadhyayH Westphal
Aug 27, 2002·Pediatric Radiology·Juan Suarez QuintanillaMayte Abeleira Pazos
May 31, 2003·Journal of Cell Science·Yoshiaki Kawano, Robert Kypta
Aug 16, 2003·Bone·D P C RiceI Thesleff
Sep 25, 2003·Surgical and Radiologic Anatomy : SRA·G CaptierP Montoya
Dec 26, 2003·The New England Journal of Medicine·Erming TianJohn D Shaughnessy
Aug 12, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·B Frank Eames, Jill A Helms
Dec 4, 2004·Development·Hongliang HuFanxin Long
Mar 11, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Karianne FjeldKeijo Luukko
Sep 8, 2005·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Xuguang NiePäivi Kettunen
Oct 1, 2005·Journal of Molecular Histology·Xuguang Nie

❮ Previous
Next ❯

Citations

Nov 15, 2011·Gene·David G MonroeJennifer J Westendorf
Apr 18, 2014·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Antonio Di IevaManfred Tschabitscher
May 11, 2007·Differentiation; Research in Biological Diversity·Sonia Pinho, Christof Niehrs
Aug 6, 2008·Developmental Biology·B McBratney-OwenG M Morriss-Kay
Feb 11, 2010·Developmental Biology·Oliver LievenUlrich Rüther

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.