PMID: 9182849Jun 30, 1997Paper

Developmental expression of GABA(A) receptor subunit and GAD genes in mouse somatosensory barrel cortex

The Journal of Comparative Neurology
P GolshaniE G Jones

Abstract

In situ hybridization histochemistry with radioactive cRNA probes was used to study patterns of gene expression for alpha1, alpha2, alpha4, alpha5, beta1, beta2, and gamma2 subunit mRNAs of typeAgamma aminobutyric acid (GABA(A)) receptors and for 67-kDa glutamic acid decarboxylase (GAD67) mRNA in mouse barrel cortex during the period (postnatal days 1-12; P1-P12) when thalamocortical innervation of layer IV barrels is occurring. The alpha1, beta2, and gamma2 subunit mRNAs increased substantially with age, especially in layers V and VI, and throughout the period studied, invariably had the same laminar-specific patterns of expression. All three mRNAs were highly expressed in the dense cortical plate at P1. In layer IV after differentiation of barrels, they were expressed in cells of both barrel walls and hollows but especially in the walls. The alpha2, alpha4, alpha5, and beta1 subunit mRNAs were expressed at lower levels and had different laminar patterns of distribution; alpha2 and alpha4 showed switches between layers over time; alpha5 was invariably associated with the subplate or its derivative, beta1 with layer IV. Levels of alpha2 mRNA did not change over time; alpha4 and beta1 mRNAs increased and alpha5 decreased. GAD67 ...Continue Reading

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Citations

Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M M HuntsmanE G Jones
Jul 9, 2009·Proceedings of the National Academy of Sciences of the United States of America·Peijun LiMolly M Huntsman
Sep 22, 2011·Developmental Neuroscience·Scott M PaluszkiewiczMolly M Huntsman
Oct 7, 2003·Annual Review of Neuroscience·Jeffrey L Noebels
Oct 16, 2015·Biochimica Et Biophysica Acta·Bindu NairMargaret T T Wong-Riley
Aug 25, 2009·Neurochemical Research·Christopher P TurnerChun Liu
Nov 4, 2009·Experimental Brain Research·Christopher Paul TurnerChun Liu
Nov 28, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ricardo Noboro IsayamaEdna Nanami Yamasaki
May 12, 2007·Journal of Neurophysiology·Ozlem BozdagiGeorge W Huntley
Jan 11, 2019·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Hoda Khoshdel-SarkariziHossein Haghir
Jul 22, 2019·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Hoda Khoshdel-SarkariziHossein Haghir

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