Mar 1, 1994

Developmental expression of human cartilage matrix protein

Developmental Dynamics : an Official Publication of the American Association of Anatomists
S Mundlos, B Zabel

Abstract

Cartilage matrix protein (CMP) is a non-collagenous component of cartilage with a yet unknown function. In this study we used in situ hybridization to investigate the temporal and spatial distribution of CMP transcripts during human embryonic and early fetal development, and compared it to the pattern of expression observed for collagen types I, II, X, and decorin. The distribution of CMP and collagen type II transcripts followed a similar pattern in the embryonic bone anlage, the fetal growth plate, and the developing vertebral column. Expression was highest in the upper hypertrophic and lower proliferative zone, whereas calcified cartilage was negative throughout the different stages of bone development. Chondrocytes of calcified cartilage, however, were not quiescent but expressed collagen type X. The onset of collagen type X expression was linked to hypertrophy and occurred before calcification became apparent. In contrast, decorin and collagen type I were highly expressed in bone and perichondrium but not in growth plate cartilage. During the development of the synovial joints a different pattern of expression emerged. After formation of the joint cavity, there was a halt in expression of CMP but not of collagen type II in...Continue Reading

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  • Citations29

Citations

Mentioned in this Paper

Bone Development
Collagen Type X
Embryo
Fetal Development Aspects
Articular System
Entire Retina
Chondrocyte Differentiation
Hypertrophic Cardiomyopathy
Transcription, Genetic
Structure of Articular Cartilage

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