Developmental expression of mouse Krüppel-like transcription factor KLF7 suggests a potential role in neurogenesis

Developmental Biology
Friedrich LaubF Ramirez

Abstract

To identify potential functions for the Krüppel-like transcription factor KLF7, we have determined the spatiotemporal pattern of gene expression during embryogenesis and in the adult organism. We show that the profile of Klf7 expression predominantly involves the central and peripheral nervous systems and is broadly identified by three separate phases. The first phase occurs early in embryogenesis with increasingly strong expression in the spinal cord, notably in motor neurons of the ventral horn, in dorsal root ganglia, and in sympathetic ganglia. The second robust phase of Klf7 expression is confined to the early postnatal cerebral cortex and is downregulated thereafter. The third phase is characterized by high and sustained expression in the adult cerebellum and dorsal root ganglia. Functionally, these three phases coincide with establishment of neuronal phenotype in embryonic spinal cord, with synaptogenesis and development of mature synaptic circuitry in the postnatal cerebral cortex, and with survival and/or maintenance of function of adult sensory neurons and cerebellar granule cells. Consistent with Klf7 expression in newly formed neuroblasts, overexpression of the gene in cultured fibroblasts and neuroblastoma cells re...Continue Reading

References

Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·H H HengL C Tsui
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·P ShockettD G Schatz
Nov 15, 1996·Science·Y Tanabe, T M Jessell
Feb 1, 1997·Current Opinion in Neurobiology·M E HattenN Heintz
Apr 4, 1997·The Journal of Biological Chemistry·N P KoritschonerL C Patrito
May 6, 1998·Current Opinion in Neurobiology·S Pfaff, C Kintner
Jun 15, 1999·Trends in Biochemical Sciences·J Turner, M Crossley
Jul 20, 1999·The Journal of Biological Chemistry·M A WaniJ B Lingrel
Sep 30, 1999·Journal of Neurobiology·R Yuste, M Sur
Apr 15, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J K LeeH Suh-Kim
Apr 15, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S OhnishiM Terada
Oct 21, 2000·Genes & Development·B Lemon, R Tjian
Feb 13, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·H SumiyoshiF Ramirez

❮ Previous
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Citations

May 19, 2006·Cellular and Molecular Neurobiology·Danette J NicolayAdil J Nazarali
Jul 27, 2001·Mechanisms of Development·F LaubS Friedman
Dec 24, 2005·Nature Reviews. Cancer·Benjamin D Rowland, Daniel S Peeper
Apr 25, 2012·Proceedings of the National Academy of Sciences of the United States of America·Murray G BlackmoreJohn L Bixby
Oct 11, 2013·Open Biology·David E NelsonHeike Laman
Feb 7, 2007·Molecular and Cellular Biology·Alister P W FunnellMerlin Crossley
Jan 20, 2004·Molecular and Cellular Biology·Silvia SmaldoneFrancesco Ramirez
Jun 21, 2005·Molecular and Cellular Biology·Friedrich LaubFrancesco Ramirez
Oct 21, 2010·Physiological Reviews·Beth B McConnell, Vincent W Yang
Jul 16, 2015·The European Journal of Neuroscience·Anand KrishnanDouglas W Zochodne
Feb 4, 2010·Molecular and Cellular Neurosciences·Matthew B VeldmanDaniel Goldman
Apr 24, 2013·Animal Science Journal = Nihon Chikusan Gakkaihō·Zhi-Wei ZhangHui Li
Jun 16, 2011·Developmental Neurobiology·Darcie L Moore, Jeffrey L Goldberg
Apr 20, 2016·Neurological Research·Ying WangLi-Xin Guan
Nov 12, 2013·American Journal of Human Genetics·Charlotte J SumnerHenry Houlden
Nov 13, 2012·Developmental Biology·Zeni Wu, Suqing Wang
Mar 18, 2015·ELife·Yael OrenIrit Gat-Viks
Jul 2, 2016·Gene Expression Patterns : GEP·Sunil BhattaraiQin Liu
Nov 5, 2016·Journal of Proteome Research·Paula DuekLydie Lane
Jun 4, 2011·Molecular and Cellular Neurosciences·Darcie L MooreJeffrey L Goldberg
Nov 26, 2010·Experimental Cell Research·Massimiliano CaiazzoUmberto di Porzio
Feb 27, 2013·Acta Biochimica Et Biophysica Sinica·Zhiwei ZhangNing Wang
May 12, 2009·Neuroscience Letters·Kyoung Hoon JeongKyung-Ok Cho
Mar 2, 2017·Development·Agnieszka B BialkowskaSandeep K Mallipattu
Sep 25, 2004·Journal of Neuroscience Research·Alessandra ValerioPierfranco Spano
Jul 28, 2018·Journal of Animal Science·Thaise P MeloRoberto Carvalheiro
Dec 15, 2010·IUBMB Life·Verónica AndreoliJose Luis Bocco
Mar 7, 2019·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Shigeaki SugiyamaKeiichi I Nakayama
Jul 10, 2001·The Journal of Biological Chemistry·J J Bieker
Apr 1, 2011·The Journal of Comparative Neurology·Matthew J EcklerBin Chen
Mar 14, 2018·Molecular Neurobiology·Godwin SokporTran Tuoc
Aug 24, 2018·Animals : an Open Access Journal From MDPI·Habtamu Abera GoshuPing Yan
Dec 19, 2019·Scientific Reports·Rajshekhar A KoreJawahar L Mehta
Jul 19, 2012·Birth Defects Research. Part A, Clinical and Molecular Teratology·Deidre R KruppUNKNOWN National Birth Defects Prevention Study
Jul 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sahba TabrizifardHoward T Petrie

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