Developmental expression of myeloid leukemia inhibitory factor gene in preimplantation blastocysts and in extraembryonic tissue of mouse embryos.

Molecular and Cellular Biology
F Conquet, P Brûlet

Abstract

Murine leukemia inhibitory factor (LIF) protein is a growth factor which has the ability to maintain the developmental potential of pluripotent embryonic stem cells through a specific receptor. We have examined the expression pattern of the LIF gene from the preimplantation stage (3.5 days post coitum) to the midgestation stage (12.5 days post coitum) of the mouse embryo. LIF transcripts were detected at the preimplantation blastocyst stage, whereas no transcripts were detectable in embryonic stem cells. LIF gene transcription continued in the extraembryonic tissue of the 7.5-day and in the placenta of 9.5-, 10.5-, and 12.5-day post coitum embryos. No transcripts were detected in the embryo proper of the corresponding stages. Our results suggest that this growth factor is synthesized in the extraembryonic part of the embryo and acts on the embryonic tissues during early mouse development.

References

May 1, 1989·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A W Burgess
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·N M GoughD Metcalf
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·E S KawasakiF P McCormick
Oct 25, 1988·Nucleic Acids Research·D P GearingN M Gough

❮ Previous
Next ❯

Citations

Sep 1, 1992·Leukemia & Lymphoma·Z EstrovR Kurzrock
Jun 1, 1994·Molecular Reproduction and Development·Z M YangM J Harper
May 1, 1993·Molecular Reproduction and Development·S K PalG M Cooper
Sep 30, 1994·Annals of the New York Academy of Sciences·C L Stewart
Sep 30, 1994·Annals of the New York Academy of Sciences·C BullettiR Parmeggiani
Aug 12, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yingchun WangDaniel A Rappolee
Jan 15, 2014·JAK-STAT·Pankaj SumanSatish Kumar Gupta
May 8, 1998·Experimental Cell Research·H ParadisR L Gendron
Sep 29, 2004·The Journal of Cell Biology·Jiro Takito, Qais Al-Awqati
Jan 1, 1992·Progress in Growth Factor Research·P Van Vlasselaer
Jan 1, 1995·Progress in Growth Factor Research·P L Kaye, M B Harvey
Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·D Bottorff, J C Stone
Oct 1, 1991·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S PampferJ W Pollard
Dec 27, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Tianbing DingBibhash C Paria
Jul 1, 1994·Journal of the Society for Gynecologic Investigation·M H MitchellS Oehninger
Dec 26, 2001·Archives of Medical Research·L Díaz-Cueto, G L Gerton
Jan 1, 1993·Reproductive Toxicology·C L MummeryA J van den Eijnden-Van Raaij

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.