PMID: 9436990Mar 14, 1998Paper

Developmental expression of spectrins in rat skeletal muscle

Molecular Biology of the Cell
D ZhouR J Bloch

Abstract

Skeletal muscle contains spectrin (or spectrin I) and fodrin (or spectrin II), members of the spectrin supergene family. We used isoform-specific antibodies and cDNA probes to investigate the molecular forms, developmental expression, and subcellular localization of the spectrins in skeletal muscle of the rat. We report that beta-spectrin (betaI) replaces beta-fodrin (betaII) at the sarcolemma as skeletal muscle fibers develop. As a result, adult muscle fibers contain only alpha-fodrin (alphaII) and the muscle isoform of beta-spectrin (betaISigma2). By contrast, other types of cells present in skeletal muscle tissue, including blood vessels and nerves, contain only alpha- and beta-fodrin. During late embryogenesis and early postnatal development, skeletal muscle fibers contain a previously unknown form of spectrin complex, consisting of alpha-fodrin, beta-fodrin, and the muscle isoform of beta-spectrin. These complexes associate with the sarcolemma to form linear membrane skeletal structures that otherwise resemble the structures found in the adult. Our results suggest that the spectrin-based membrane skeleton of muscle fibers can exist in three distinct states during development.

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Citations

Nov 10, 2007·Clinical Reviews in Allergy & Immunology·John G Routsias, Athanasios G Tzioufas
Jul 17, 2001·Brain Research. Developmental Brain Research·J A UrsittiR J Bloch
Jul 10, 2003·Autoimmunity Reviews·Kai U UlbrichtTorsten Witte
Nov 10, 2000·Molecular Biology of the Cell·A Kontrogianni-KonstantopoulosE J Benz
May 17, 2000·The Journal of Cell Biology·M HammarlundE M Jorgensen
Oct 17, 2007·Experimental Gerontology·Elise DargelosPatrick Cottin
Jul 30, 2005·Neuromuscular Disorders : NMD·Patrick Reed, Robert J Bloch
May 16, 2013·Biochimica Et Biophysica Acta·Beata MachnickaAleksander F Sikorski
Jan 6, 2011·FEMS Immunology and Medical Microbiology·Renato E CappelloJames P Nataro
Aug 19, 2015·Experimental Biology and Medicine·Steven R GoodmanWarren E Zimmer
Apr 11, 2000·Microscopy Research and Technique·E Kordeli
Jun 11, 2005·Muscle & Nerve·Miwa TakamureSatoshi Ueno
Mar 15, 2000·Muscle & Nerve·M W WilliamsR J Bloch
May 1, 2000·Journal of the Science of Food and Agriculture·E Heather MorrisonPeter P Purslow
Apr 20, 2004·Journal of Cell Science·Elisabeth A Cox, Jeff Hardin

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