PMID: 11335123May 4, 2001Paper

Developmental expression patterns of the signaling adapters FRS-2 and FRS-3 during early embryogenesis

Mechanisms of Development
K McDougallS O Meakin

Abstract

Two fibroblast growth factor (FGF) receptor substrates (FRS2 and FRS3) are involved in downstream signaling from activated FGF receptors and neurotrophin-activated Trk receptors. Despite the importance of signaling from these factors in embryogenesis, FRS2 and FRS3 expression patterns during development are unknown. In this study we characterize the expression of FRS2 and FRS3 from E7 to parturition and in adult murine tissues. Both are first detected in whole E8.5 CD1 mouse embryos. FRS2 is detected as early as E7 in the developing syncytiotrophoblast, later in the neural tube (NT) and in many adult and fetal tissues. FRS3 is more restricted in location than FRS2 (fetal NT, heart, stomach, liver and some adult tissues), and is expressed predominantly in the ventricular layer of the developing NT and brains of murine embryos.

References

Jun 5, 1995·The Journal of Comparative Neurology·Y MuragakiV M Lee
Dec 1, 1996·Cytokine & Growth Factor Reviews·M Goldfarb
May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·S OrtegaC Basilico

❮ Previous
Next ❯

Citations

Feb 25, 2003·Annual Review of Neuroscience·Rosalind A Segal
Jan 16, 2016·Seminars in Cell & Developmental Biology·Xiaokun LiFen Wang
Jul 20, 2011·Birth Defects Research. Part A, Clinical and Molecular Teratology·Partha MukhopadhyayM Michele Pisano
Oct 16, 2004·Biochemical and Biophysical Research Communications·Lin HuangNobuo Tsuchida
Mar 5, 2013·International Journal of Molecular Sciences·Melanie MeisterRitva Tikkanen
Sep 18, 2007·Genesis : the Journal of Genetics and Development·Yongshun LinFen Wang
Feb 15, 2019·Frontiers in Genetics·Cong WangFen Wang
Aug 5, 2006·Cellular Signalling·Adam W AveryAnne B Vojtek
Sep 6, 2015·Genes & Development·J Richard BrewerPhilippe Soriano

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.