PMID: 12136507Jul 26, 2002Paper

Developmental neurobiology of childhood stress and trauma

The Psychiatric Clinics of North America
Martin H TeicherCarryl P Navalta

Abstract

Severe early stress and maltreatment produces a cascade of events that have the potential to alter brain development. The first stage of the cascade involves the stress-induced programming of the glucocorticoid, noradrenergic, and vasopressin-oxytocin stress response systems to augment stress responses. These neurohumors then produce effects on neurogenesis, synaptic overproduction and pruning, and myelination during specific sensitive periods. Major consequences include reduced size of the mid-portions of the corpus callosum; attenuated development of the left neocortex, hippocampus, and amygdala along with abnormal frontotemporal electrical activity; and reduced functional activity of the cerebellar vermis. These alterations, in turn, provide the neurobiological framework through which early abuse increases the risk of developing post-traumatic stress disorder (PTSD), depression, symptoms of attention-deficit/hyperactivity, borderline personality disorder, dissociative identity disorder, and substance abuse.

References

Jan 1, 1978·Psychoneuroendocrinology·A Ardeleanu, N Sterescu
Nov 1, 1977·The Journal of Nervous and Mental Disease·R G Heath
Mar 1, 1979·Journal of Neurology, Neurosurgery, and Psychiatry·I Jensen, J K Larsen
Dec 1, 1978·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·D M Reynolds, M A Jeeves
Jan 1, 1978·International Journal of Psychiatry in Medicine·R K Davies
Nov 1, 1975·Experimental Neurology·R S Snider, A Maiti
Jun 1, 1977·Archives of Neurology·J G ChiF H Gilles
Dec 1, 1976·Experimental Neurology·R S SniderS R Snider
Jul 11, 1975·Brain and Language·D L MolfeseD S Palermo
Jan 1, 1975·Developmental Psychobiology·D S OltonE Howard
Sep 1, 1992·Brain and Cognition·R W Thatcher
Nov 1, 1992·Pharmacology, Biochemistry, and Behavior·D M WittT R Insel
Mar 1, 1992·Comprehensive Psychiatry·R J Muller
Apr 1, 1992·Journal of Personality and Social Psychology·A J TomarkenR C Doss
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M S LidowP Rakic
Nov 19, 1991·Brain Research. Developmental Brain Research·M H TeicherR J Baldessarini
Dec 17, 1991·Brain Research. Developmental Brain Research·M F Eckenhoff, P Rakic
Jul 1, 1991·Acta Psychiatrica Scandinavica·M AratóD J MacCrimmon
Sep 1, 1991·Journal of the American Academy of Child and Adolescent Psychiatry·L J KiserD B Pruitt
Nov 1, 1991·Archives of Neurology·J D Schmahmann
Nov 5, 1990·Brain Research·M P ArmaniniR M Sapolsky
Jul 1, 1990·Developmental Psychobiology·C M KuhnS M Schanberg
Dec 1, 1990·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·P Flor-HenryL T Yeudall
Aug 1, 1986·Electroencephalography and Clinical Neurophysiology·R W ThatcherM Hrybyk
Jul 1, 1989·Brain and Language·R J Simonds, A B Scheibel
Jan 22, 1988·Neuroscience Letters·J D BarksM V Johnston
Jan 1, 1988·Annual Review of Neuroscience·R W Williams, K Herrup
Oct 1, 1987·Acta Psychiatrica Scandinavica·B M Barraclough
Jan 12, 1988·Brain Research·A S BerrebiV H Denenberg

❮ Previous
Next ❯

Citations

Jul 5, 2006·Archives of General Psychiatry·Kerstin J PlessenBradley S Peterson
Nov 29, 2005·European Archives of Psychiatry and Clinical Neuroscience·Robert F AndaWayne H Giles
Feb 12, 2013·European Child & Adolescent Psychiatry·Johan IsakssonFrank Lindblad
Dec 17, 2009·Clinical Child and Family Psychology Review·Christopher A KearneyAmie Lemos-Miller
May 5, 2010·Journal of Abnormal Child Psychology·Tamar MendelsonPhilip J Leaf
May 9, 2012·Reviews in Endocrine & Metabolic Disorders·Joseph Nuñez
Aug 31, 2013·Child Abuse & Neglect·Ingrid D'avila FranckeRodrigo Grassi-Oliveira
Apr 15, 2004·Clinical Psychology Review·Linda J Luecken, Kathryn S Lemery
Jul 13, 2013·Revue D'épidémiologie Et De Santé Publique·M-A Charles
May 7, 2003·Neuroscience and Biobehavioral Reviews·Martin H TeicherDennis M Kim
Oct 29, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Christian WienbruchBrigitte Rockstroh
Apr 15, 2005·La Revue du praticien·Alexandra Pham-Scottez, Julien-Daniel Guelfi
Feb 16, 2006·Development and Psychopathology·Linda J Luecken, Bradley M Appelhans
Dec 13, 2006·Development and Psychopathology·Megan R GunnarUNKNOWN Early Experience, Stress, and Prevention Network
Apr 22, 2008·Development and Psychopathology·Darlene A KertesJeffrey D Long
Oct 25, 2011·Development and Psychopathology·Brittany R Howell, Mar M Sanchez
Apr 22, 2009·Psychological Bulletin·Sheila E CrowellMarsha M Linehan
Feb 24, 2009·Nature Neuroscience·Patrick O McGowanMichael J Meaney
Sep 13, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Tie Yuan ZhangMichael J Meaney
Jan 4, 2013·Journal of Trauma & Dissociation : the Official Journal of the International Society for the Study of Dissociation (ISSD)·Julia SengIsrael Liberzon
Sep 10, 2011·Journal of Pediatric Psychology·Margaret J Briggs-GowanJulian D Ford
Aug 15, 2006·Annual Review of Psychology·Megan Gunnar, Karina Quevedo
Mar 19, 2005·Journal of Addictive Diseases·Moira PlantPatrick Miller
Sep 10, 2005·Journal of Trauma & Dissociation : the Official Journal of the International Society for the Study of Dissociation (ISSD)·Onno van der HartBessel A van der Kolk
Jun 1, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Charlis RainekiRegina M Sullivan
Aug 11, 2010·Pediatrics·Jennie G NollPenelope K Trickett
Jul 20, 2013·American Journal of Public Health·Brandon D L MarshallThomas Kerr
Oct 28, 2010·The Australian and New Zealand Journal of Psychiatry·Louise K NewmanJoanne Allen
Aug 29, 2013·International Journal of Circumpolar Health·Diane PayneJared W Parrish
Mar 18, 2010·Cognitive, Affective & Behavioral Neuroscience·Françoise S MaheuMonique Ernst
Jul 4, 2009·The Journal of Clinical Psychiatry·Karen RitchieAlain Malafosse
Dec 12, 2013·Current Psychiatry Reports·Marissa Cummings, Steven J Berkowitz

❮ Previous
Next ❯

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