Developmental origin of neural stem cells: the glial cell that could.

Stem Cell Reviews and Reports
Laura Grabel

Abstract

Since their identification, there has been tremendous interest in adult neural stem cells, in part based upon their potential therapeutic uses in understanding and treating neurological disorders. But what's the origin of these cells in the embryo? We outline here the onset of neural specification in the vertebrate embryo and describe the molecular mechanisms regulating patterning of the central nervous system (CNS). We trace the lineage of the multipotential stem cell of the nervous system from embryonic neuroepithelial cell to adult astrocyte-like neural stem cell. As these stem cells emerge throughout development and in the adult, they appear to be predetermined to a specific neuronal or glial fate. Finally, we compare the properties of embryonic stem cell-derived neural stem cells and CNS-derived neural stem cells.

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Citations

Apr 25, 2012·Stem Cell Reviews and Reports·Vincent Tropepe, Kursad Turksen
Jun 4, 2013·Expert Opinion on Drug Discovery·Thorsten Gorba, Luciano Conti
Apr 18, 2015·Neural Regeneration Research·Michael Telias, Dalit Ben-Yosef
Dec 5, 2014·Stem Cells and Development·Erin BandaLaura Grabel
Jan 1, 2014·Molecular and Cellular Therapies·Simona CasarosaLuciano Conti
Mar 27, 2020·Frontiers in Neuroscience·Michael J RigbyLuigi Puglielli

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