Developmental Origin of the Cardiac Conduction System: Insight from Lineage Tracing

Pediatric Cardiology
Rajiv A MohanVincent M Christoffels

Abstract

The components of the cardiac conduction system (CCS) generate and propagate the electrical impulse that initiates cardiac contraction. These interconnected components share properties, such as automaticity, that set them apart from the working myocardium of the atria and ventricles. A variety of tools and approaches have been used to define the CCS lineages. These include genetic labeling of cells expressing lineage markers and fate mapping of dye labeled cells, which we will discuss in this review. We conclude that there is not a single CCS lineage, but instead early cell fate decisions segregate the lineages of the CCS components while they remain interconnected. The latter is relevant for development of therapies for conduction system disease that focus on reprogramming cardiomyocytes or instruction of pluripotent stem cells.

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Citations

Sep 14, 2019·Cell Cycle·Jessica PichéGregor Andelfinger
Nov 20, 2018·F1000Research·Angeliqua SayedDavid Sassoon
Jul 16, 2019·Biochimica Et Biophysica Acta. Molecular Cell Research·Vincent W W van EifVincent M Christoffels
Dec 16, 2020·ACS Biomaterials Science & Engineering·Ali MousaviHossein Baharvand
Aug 27, 2021·Journal of Cardiovascular Development and Disease·Caroline ChoquetLucile Miquerol

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Methods Mentioned

BETA
transgenic

Software Mentioned

nLaacZ

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