Developmental origin of vaginal epithelium.

Differentiation; Research in Biological Diversity
Takeshi Kurita

Abstract

The developmental origin of vaginal epithelium has been controversial for nearly a century, with speculation that vaginal epithelium originates from the Müllerian duct, Wolffian duct, and/or urogenital sinus. None of these possibilities have been definitively proven or disproven by direct scientific data. To define precisely the origin of vaginal epithelium, epithelial cells of the Müllerian duct, Wolffian duct, or urogenital sinus were fluorescently labeled in mouse embryos by crossing tdTomato-EGFP dual-reporter transgenic mice with transgenic mouse lines that express Cre-recombinase in each type of epithelium. In embryos and newborn mice, the vagina consisted of fused Müllerian ducts plus the sinus vagina of urogenital sinus origin. However, the proportion of the sinus vagina was significantly reduced as the Müllerian vagina grew caudally. By postpartum day 7, the Müllerian vagina extended to the caudal end of the body, whereas the sinus vagina remained only at the junction between the vagina and perineal skin. As the vagina opened in puberty, urogenital sinus epithelium was detected only in the vulva, but not in the vagina. Additionally, from embryo to adult stages, residual Wolffian duct epithelium was present in the dorso...Continue Reading

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Citations

Mar 6, 2012·Cell and Tissue Research·Tadaaki NakajimaTomomi Sato
May 10, 2012·PloS One·Masanori OnoSerdar E Bulun
Nov 1, 2013·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Elisabeth J PechrigglHelga Fritsch
Jul 1, 2014·Journal of Lower Genital Tract Disease·Olaf Reich, Helga Fritsch
Jun 12, 2012·Differentiation; Research in Biological Diversity·Monica M LarondaTakeshi Kurita
Dec 15, 2015·Differentiation; Research in Biological Diversity·Lerrie Ann IpulanGen Yamada
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Oct 20, 2011·Molecular and Cellular Endocrinology·Thomas E SpencerJustyna Filant
May 27, 2011·Differentiation; Research in Biological Diversity·Takeshi Kurita
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Nov 9, 2016·Proceedings of the National Academy of Sciences of the United States of America·Christine E LarkinsMartin J Cohn
May 11, 2016·Molecular Endocrinology·Jumpei TerakawaTakeshi Kurita
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Jul 28, 2019·Journal of Anatomy·Amelia Franke-RadowieckaJerzy Kaleczyc
Sep 27, 2019·Frontiers in Immunology·Namarta KaliaManpreet Kaur
Jun 24, 2020·Cell Death and Differentiation·Jumpei TerakawaTakeshi Kurita
Feb 21, 2019·Proceedings of the National Academy of Sciences of the United States of America·Jumpei TerakawaTakeshi Kurita
Mar 13, 2021·Differentiation; Research in Biological Diversity·Myles H Alderman, Hugh S Taylor
Apr 8, 2021·Reproductive Sciences·Jennifer M McCrackenJulie C E Hakim
Apr 24, 2018·Differentiation; Research in Biological Diversity·Gerald R CunhaLaurence S Baskin
May 15, 2015·Development·Kylie M GeorgasCathy Mendelsohn

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