Developmental origins of brain tumors.

Current Opinion in Neurobiology
Chong Liu, Hui Zong

Abstract

Brain tumors are devastating owing to the high fatality rate and the devastating impact on life qualities of patients. Recent advancement of comparative transcriptome profiling tools and mouse genetic models has greatly deepened our understanding of the developmental origins of these tumors, which could lead to effective therapeutic strategies. We review recent progresses in three types of brain tumors: ependymoma, medulloblastoma, and malignant glioma. The conceptual framework established by these studies converged on three important aspects. First, subtypes in each tumor group originate from distinct cell types. Second, each cell-of-origin is uniquely susceptible to some but not other genetic mutations. Lastly, mutant stem cells may not transform until they differentiate into more restricted progenitor cell type. Overall, these findings indicate the existence of intricate interactions between gene mutations and developmental program for the formation of brain tumors.

References

Feb 26, 2000·Science·F H Gage
May 11, 2005·Cell·Hui ZongLiqun Luo
Oct 18, 2005·Cancer Cell·Michael D TaylorRichard J Gilbertson
Nov 23, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Piergiorgio ModenaGabriella Sozzi
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Mandar Deepak MuzumdarHui Zong
Nov 28, 2007·Annual Review of Pathology·Richard J Gilbertson, David W Ellison
Dec 20, 2008·Nature Reviews. Neuroscience·Akiko NishiyamaXiaoqin Zhu
Dec 16, 2010·Cancer Cell·Anders I PerssonWilliam A Weiss
Dec 23, 2011·Genes & Development·Krishna P L BhatKenneth D Aldape
Apr 6, 2012·PloS One·Bosiljka TasicLiqun Luo

❮ Previous
Next ❯

Citations

Mar 19, 2014·Seminars in Cell & Developmental Biology·Derek H Janssens, Cheng-Yu Lee
Oct 28, 2015·Current Opinion in Cell Biology·Suk Hyung Lee, Michael M Shen
Oct 27, 2015·CNS Oncology·Nives Pećina-Šlaus, Anja Kafka
Dec 23, 2014·Translational Neuroscience·Kate Marie Lewis, Claudia Petritsch
Sep 2, 2014·Cell Reports·Zhu A WangMichael M Shen
Nov 25, 2014·Cell and Tissue Research·Fredrik J SwartlingAnders I Persson
Jul 28, 2016·Journal of Cellular Physiology·Claudia CapdevilaJoaquín Martí
Oct 1, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Peng ZhangYu Hua Zhou
May 25, 2018·BMC Cancer·Sini L KarjalainenJoonas A Haapasalo
Aug 6, 2020·Frontiers in Cell and Developmental Biology·Alexandre PerlaRafael Roesler
May 7, 2020·Frontiers in Cell and Developmental Biology·Roberta Azzarelli
Mar 19, 2019·Frontiers in Neuroscience·Shohreh MajdZohreh Majd
Aug 28, 2020·Frontiers in Oncology·Zoya Yan, Shanzhi Wang
Mar 9, 2018·Frontiers in Cellular Neuroscience·Katarzyna Pogoda, Paul A Janmey
Sep 24, 2019·Biomaterials·Jinbing XieXiaoyuan Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Cancer -Omics

A variety of different high-throughput technologies can be used to identify the complete catalog of changes that characterize the molecular profile of cohorts of tumor samples. Discover the latest insights gained from cancer 'omics' in this feed.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Cancer Stem Cells in Glioblastoma

Glioblastoma is the most common and aggressive type of brain tumor. It contains a population of tumor initiating stem cell-like cells known as cancer stem cells. Investigations are ongoing into these cancer stem cells found in these solid tumors which are highly resistance to treatment. Here is the latest research on cancer stem cells in glioblastoma.