Developmental origins of chronic inflammation: a review of the relationship between birth weight and C-reactive protein

Annals of Epidemiology
Leslie deRosset, Kelly L Strutz

Abstract

The developmental origins of adult disease hypothesis suggests that the intrauterine environment may program postnatal health outcomes through mechanisms such as chronic inflammation. The purpose of this article was to review the literature on the association between infant birth weight and C-reactive protein (CRP), markers of the fetal environment and inflammation, respectively. We used PubMed, Google Scholar, Web of Science, ScienceDirect, the citation lists of the reviewed literature, and recommendations from experts in the field to identify potential articles. Inclusion criteria for the studies, regardless of study design, included human subjects, documented or self-reported infant birth weight, and a minimum of one measurement of CRP (during childhood, adolescence, or adulthood). Several studies demonstrated a statistically significant inverse association between birth weight and CRP in adulthood, although in many cases only after controlling for markers of current adiposity. No studies significantly linked birth weight to CRP in childhood or adolescence. Longitudinal studies, including multigenerational studies, are needed to further understand whether adult CRP has origins in the fetal environment.

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Citations

Apr 12, 2016·Frontiers in Immunology·Christine G ParksDale P Sandler
Dec 18, 2016·Behavioural Brain Research·Jeffrey R MeaselleJennifer C Ablow
Jul 20, 2017·Journal of Developmental Origins of Health and Disease·C W KuzawaT W McDade
Mar 27, 2018·Biological Reviews of the Cambridge Philosophical Society·Douglas B Kell, Etheresia Pretorius
Nov 14, 2019·International Journal of Molecular Sciences·Rafa S AlmeerHatem K Amin
Oct 28, 2016·European Child & Adolescent Psychiatry·Rodrigo B MansurElisa Brietzke

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