Developmental outcomes of Japanese children born through Assisted Reproductive Technology (ART) in toddlerhood

The Journal of Obstetrics and Gynaecology Research
Sayaka AokiHaruhiko Sago

Abstract

This study aimed to investigate developmental outcomes of Japanese babies born through Assisted Reproductive Technology (ART) at ages 2 and 3. The data were gathered from 1085 children in a hospital-based cohort study conducted in Japan. The children's level of development was assessed through a parent-rated questionnaire, the Kinder Infant Development Scale, which consists of nine developmental domains. We compared the development of children born through ART and those born naturally by conducting analyses of covariance. For the analyses, the effect of maternal age, family income, parental education and multiple birth were controlled for. At 24 months, no significant difference was found between children born through ART and those born naturally in development in any domain. At 36 months, a significant difference was found in development of Receptive language (F (1, 845) = 6.148, P = 0.013), Expressive language (F (1, 845) = 4.060, P = 0.044) and Language concept (F (1, 845) = 6.968, P = 0.008). For these domains, children born through ART had a significantly higher developmental age compared to children born naturally. At age 2, no significant difference was found between the children born through ART and those born naturally...Continue Reading

References

May 5, 2009·Fertility and Sterility·Jaime KnopmanNicole Noyes
Jul 7, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Sarah D McDonaldUNKNOWN Knowledge Synthesis Group
Nov 30, 2010·Human Reproduction·J ReefhuisUNKNOWN National Birth Defects Prevention Study
Dec 9, 2015·The Journal of Obstetrics and Gynaecology Research·Keiji HashimotoHaruhiko Sago
Dec 10, 2015·Reproductive Biology and Endocrinology : RB&E·Céline Audibert, Daniel Glass

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Citations

Nov 29, 2020·American Journal of Obstetrics and Gynecology·Stephanie CheungGianpiero D Palermo

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