Developmental pattern of androgen receptor immunoreactivity in the mouse submandibular gland

Zoological Science
K Sawada, T Noumura

Abstract

We studied the immunohistochemical localization of androgen receptor in the mouse submandibular gland, and developmental profiles of its expression using polyclonal human androgen receptor antibody. In the submandibular glands of both sexes, specific immunoreactivity appeared only in cell nuclei of the acini, the intercalated ducts, the granular convoluted tubules (GCT) and the excretory striated ducts. The percentage of immunoreactive cells in each region gradually declined with age during the first 90 days of postnatal development studied. The sexual difference in the percentage of immunoreactive cells was observed in the acini on days 20 and 30 and in the GCT on day 30. Incidence of immunoreactive cells in the female was significantly smaller than that in the male. On day 60, the percentage of immunoreactive cells of these two regions turned to increase slightly in the female but continued to decline in the male, and then it became higher in the female than in the male. In addition, one-week castration did not cause any changes in the intracellular distribution of androgen receptor and the percentage of immunoreactive cells in each region of the adult gland. These results suggest that androgen receptor is localized primarily...Continue Reading

Citations

Aug 22, 2008·Journal of Molecular Histology·Shingo KurabuchiKazuo Hosoi
Jan 15, 1998·European Journal of Biochemistry·B HaendlerW D Schleuning
Oct 27, 2004·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Shingo KurabuchiKazuo Hosoi
Jan 19, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Shingo KurabuchiEdward W Gresik
Dec 19, 2007·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Yuichi MiyajiShingo Kurabuchi
Aug 20, 2005·Asian Journal of Andrology·Hong-Jun LiYu-Feng Huang
Oct 6, 2004·Equine Veterinary Journal·B BilińskaM Tischner
Aug 23, 2012·American Journal of Physiology. Endocrinology and Metabolism·Nina TrokovicYrjö T Konttinen

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