Developmental pattern of expression of BMP receptors and Smads and activation of Smad1 and Smad5 by BMP9 in mouse basal forebrain

Brain Research
Ignacio Lopez-CoviellaJan Krzysztof Blusztajn

Abstract

Basal forebrain cholinergic neurons play critical roles in the organization of brain cortical structures and in processes such as learning and memory. We have previously shown that bone morphogenetic protein (BMP) 9, a member of the transforming growth factor (TGF) beta superfamily of cytokines, is a differentiating factor for cholinergic central nervous system neurons. However, whereas the basic signal transduction pathways for most known members of the TGF-beta superfamily have been well characterized in brain and other organs, nothing is known about the signal transduction pathway of BMP9 in the brain. Here, we describe the pattern of expression of BMP receptors, including Bmpr-Ia, Bmpr-Ib, Bmpr-II, Actr-I. Actr-Ib, Actr-II and Actr-IIb, Alk-1, and Smad proteins (Smads 1-5 and Smad8) in the septal region of the basal forebrain during mouse development. Using cultured basal forebrain cells derived from embryonic day (E) 14 mice, we show that BMP9 causes phosphorylation of Smad1 and Smad5, formation of a complex of Smad4 with Samd1 and/or Smad5, and translocation of these proteins into the nucleus. These data show that BMP9 activates the canonical BMP signaling pathway and suggest that this could be one of the mechanisms respo...Continue Reading

References

Jul 1, 1992·Journal of Chemical Neuroanatomy·R P HellendallJ M Lauder
Jan 1, 1991·Progress in Neurobiology·N J Woolf
Jul 1, 1997·Trends in Neurosciences·M F MehlerJ A Kessler
Feb 20, 1998·Journal of Neuroscience Research·T EbendalS Söderström
Apr 25, 2000·The EMBO Journal·J Massagué, D Wotton
Dec 12, 2001·Brain & Development·M V JohnstonS Naidu
Jan 5, 2002·Journal of Physiology, Paris·Ignacio López-CoviellaJan Krzysztof Blusztajn
Jan 11, 2002·Developmental Biology·A von Bubnoff, K W Cho
Dec 18, 2002·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Keiji MiyazawaKohei Miyazono
Jun 18, 2003·Cell·Yigong Shi, Joan Massagué
Aug 30, 2003·Neuroscience and Biobehavioral Reviews·Christine F Hohmann
Sep 13, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Donghui ZhangRegis J O'Keefe
Jan 20, 2004·Journal of Chemical Neuroanatomy·Elliott J MufsonSteven T DeKosky
Jun 26, 2004·The European Journal of Neuroscience·Tetsuji MoriAkio Wanaka
Apr 27, 2005·The Journal of Biological Chemistry·Monica A BrownSenyon Choe

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Citations

Jul 31, 2013·Progress in Neurobiology·Shane V HegartyAideen M Sullivan
Apr 25, 2009·Tissue Engineering. Part a·Eric BergeronNathalie Faucheux
Oct 17, 2008·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Mahmud Bani-YaghoubMarianna Sikorska
Jun 18, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aletta C SchnitzlerJan Krzysztof Blusztajn
Apr 9, 2008·Development Genes and Evolution·Maurijn Van der ZeeSiegfried Roth
Apr 16, 2015·International Journal of Molecular Medicine·Li LiJinyong Luo
Mar 7, 2015·Cellular Signalling·Marc-Antoine LauzonNathalie Faucheux
Oct 17, 2013·Journal of Neuropathology and Experimental Neurology·Fumihiro WatanabeYaz Y Kisanuki
Mar 27, 2010·Journal of Neurodevelopmental Disorders·Mario MairaStefano Stifani
Feb 23, 2008·Journal of Tissue Engineering and Regenerative Medicine·P C BessaR L Reis
May 26, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elisabeth LeblancGuillaume Grenier
Jul 12, 2011·American Journal of Medical Genetics. Part a·Jill A RosenfeldLisa G Shaffer
Apr 11, 2012·Developmental Neurobiology·Allison M BondJohn A Kessler
Mar 26, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Marc-Antoine LauzonNathalie Faucheux

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