Developmental pattern of the secretion of cumulus expansion-enabling factor by mouse oocytes and the role of oocytes in promoting granulosa cell differentiation

Developmental Biology
B C VanderhydenJ J Eppig

Abstract

The expansion, or mucification, of the mouse cumulus oophorus in vitro requires the presence of an enabling factor secreted by the oocyte as well as stimulation with follicle-stimulating hormone (FSH). This study focuses on (1) the ability of mouse oocytes to secrete the enabling factor at various times during oocyte growth and maturation, (2) the temporal relationships between the development of the capacity of the oocyte to undergo germinal vesicle breakdown, the ability of the oocyte to secrete cumulus expansion-enabling factor, and the capacity of the cumulus oophorus to undergo expansion, and (3) the role of the oocyte in the differentiation of granulosa cells as functional cumulus cells. Growing, meiotically incompetent oocytes did not produce detectable amounts of cumulus expansion-enabling factor, but fully grown meiosis-arrested oocytes, maturing oocytes, and metaphase II oocytes did. Detectable quantities of enabling factor were produced by zygotes, but not by two-cell stage to morula embryos. The ability of oocytes to secrete cumulus expansion enabling factor and the capacity of cumulus cells to respond to FSH and the enabling factor are temporally correlated with the acquisition of oocyte competence to undergo germi...Continue Reading

References

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Citations

Apr 1, 1996·Molecular Reproduction and Development·R S IsmailB C Vanderhyden
Jan 28, 1998·Molecular Reproduction and Development·R ProcházkaJ Motlík
Mar 10, 1998·Molecular Reproduction and Development·J J EppigK Wigglesworth
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May 20, 2005·Cell and Tissue Research·Barbara C Vanderhyden
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Apr 14, 2006·Reproductive Biology and Endocrinology : RB&E·Fiona H Thomas, Barbara C Vanderhyden

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