Developmental Patterning as a Quantitative Trait: Genetic Modulation of the Hoxb6 Mutant Skeletal Phenotype

PloS One
C Kappen

Abstract

The process of patterning along the anterior-posterior axis in vertebrates is highly conserved. The function of Hox genes in the axis patterning process is particularly well documented for bone development in the vertebral column and the limbs. We here show that Hoxb6, in skeletal elements at the cervico-thoracic junction, controls multiple independent aspects of skeletal pattern, implicating discrete developmental pathways as substrates for this transcription factor. In addition, we demonstrate that Hoxb6 function is subject to modulation by genetic factors. These results establish Hox-controlled skeletal pattern as a quantitative trait modulated by gene-gene interactions, and provide evidence that distinct modifiers influence the function of conserved developmental genes in fundamental patterning processes.

References

Jan 1, 1988·British Journal of Neurosurgery·S WestacottR M Paxton
Oct 1, 1985·Toxicology and Applied Pharmacology·J C LambP S Sabharwal
Jul 1, 1995·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·H J HaldW Bähren
Jan 1, 1994·Journal of Cell Science. Supplement·M L Hooper
May 1, 1993·Trends in Genetics : TIG·B Rosen, R S Beddington
Jun 8, 1996·Annals of the New York Academy of Sciences·M R Capecchi
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y G YuehC Kappen
Dec 9, 1998·Nature·S L Rutherford, S Lindquist
Mar 26, 1999·Molecular Reproduction and Development·S KallapurT Doetschman
Sep 17, 1999·Radiographics : a Review Publication of the Radiological Society of North America, Inc·A R Guttentag, J K Salwen
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·R D HansonS J Korsmeyer
Dec 22, 1999·The Proceedings of the Nutrition Society·M MarkP Chambon
Sep 26, 2000·Molecular Genetics and Metabolism·K M Dipple, E R McCabe
Oct 5, 2001·Molecular and Cellular Biology·W F ShenC Largman
Jan 11, 2002·Developmental Biology·D AllanD Lohnes
Jun 7, 2002·Nature·Christine QueitschSusan Lindquist
Aug 30, 2002·Current Opinion in Genetics & Development·Julien Dubrulle, Olivier Pourquié
Feb 15, 2003·Developmental Cell·A C Burke, J L Nowicki
Jul 19, 2003·Science·Marie Kmita, Denis Duboule
Jul 19, 2003·Science·Deneen M Wellik, Mario R Capecchi
Mar 2, 1963·Canadian Medical Association Journal·W BOYD
Apr 2, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Todd A SangsterChristine Queitsch
Jul 30, 2004·Genesis : the Journal of Genetics and Development·Claudia KappenJ Michael Salbaum
Sep 17, 2005·Genes & Development·Marta CarapuçoMoisés Mallo
Jul 13, 2007·Development·Daniel C McIntyreDeneen M Wellik
Oct 27, 2009·Developmental Cell·Teddy YoungJacqueline Deschamps

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Citations

Jan 24, 2018·Evolution; International Journal of Organic Evolution·Catalina I Villamil
Feb 12, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chie NaruseMasahide Asano
May 16, 2021·Journal of Anatomy·Tijn Jan Pieter SpoormakersHarold Brommer

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