Developmental patterns of heart rate and variability in infants with persistent apnea of infancy

Early Human Development
V L SchechtmanR M Harper

Abstract

During periods of regular breathing, heart rate is slower and more variable in healthy (no history of respiratory distress syndrome) prematurely born infants with persistent apnea, relative to full-term control infants of comparable post-conceptional ages. We tested the hypothesis that the cardiovascular differences may be linked to the persistent apnea, rather than premature birth, by assessing heart rate and variability in full-term infants with persistent apnea. Thus, resting heart rate and variability were compared in full-term infants with apnea of infancy, prematurely born infants with persistent apnea, and full-term control infants. Full-term infants with persisting apnea showed slower heart rates than control infants, beginning at 4 months after birth, and enhanced heart rate variability beginning at 6 months. Healthy prematurely born infants with persistent apnea showed cardiovascular alterations similar to those of full-term infants with apnea; these alterations differed from those observed in very premature infants with histories of respiratory distress. The postnatal development of cardiovascular aberrations in infants with persistent apnea suggests that mechanisms accompanying apneic events may contribute to long-t...Continue Reading

References

Jun 19, 1976·Lancet·C GuilleminaultW C Dement
Dec 1, 1992·The Journal of Pediatrics·N N FinerA Hugh
Mar 1, 1992·American Heart Journal·M A WooR M Harper
Jun 1, 1989·Early Human Development·V L SchechtmanD P Southall
May 1, 1988·Journal of Neuropathology and Experimental Neurology·H C KinneyF H Gilles
May 1, 1987·Journal of Neuropathology and Experimental Neurology·B A BrodyF H Gilles

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Citations

Oct 12, 2014·Paediatric Respiratory Reviews·Rosemary S C Horne, Gillian M Nixon
Jun 6, 2013·Respiratory Physiology & Neurobiology·James R WilliamsonDavid Paydarfar
May 24, 2006·Expert Review of Cardiovascular Therapy·Rosemary S C Horne
Sep 1, 1998·Acta Neuropsychiatrica·P van Geert, C de Weerth
Nov 15, 2016·Frontiers in Neurology·Eran Elhaik
Oct 13, 2020·Frontiers in Pediatrics·Kathleen LimPeter A Dargaville

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