Developmental plasticity and its relevance to assisted human reproduction

Human Reproduction
Tessa J Roseboom

Abstract

The advent of assisted reproduction has allowed the conception of millions of individuals who otherwise would not have existed. Although most ART children are born healthy, there is increasing awareness of the plasticity of the human embryo causing concerns about potential long-term consequences of ART for the growth, development and health of this growing population of individuals. Evidence from studies in animals and humans suggest that physiology and metabolism may be permanently affected by ART. It suggests that ART children may be at increased risk of later cardiometabolic diseases. Part of this increased susceptibility to cardiometabolic diseases seems to be due to parental predisposition, while part of the increased susceptibility seems to be due to the ART procedure itself. Due to the fast development of new techniques in ART, it is unclear whether newer techniques are associated with similar risks. There is evidence to suggest that the newer techniques are safer, but the rapid developments in reproductive medicine and ever increasing indications for ART make it difficult to draw conclusions. Until more is known about the effectiveness and safety of ART for the broader indications in which ART is currently used, caution...Continue Reading

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Citations

Jun 19, 2018·Human Reproduction·Matheus RoquePeter Humaidan
Jan 25, 2019·Panminerva Medica·Carlos DosoutoPeter Humaidan
Feb 18, 2019·Biology of Reproduction·Pierre Comizzoli, William V Holt
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Oct 1, 2020·International Journal of Molecular Sciences·Ximo Garcia-DominguezFrancisco Marco-Jiménez
Feb 23, 2020·Human Reproduction Open·Catherine M CastilloDaniel R Brison
Jul 30, 2020·Animals : an Open Access Journal From MDPI·Ximo Garcia-DominguezFrancisco Marco-Jiménez
Aug 15, 2020·Evolution, Medicine, and Public Health·Zaneta M Thayer
Aug 8, 2019·European Journal of Pediatrics·D B KuiperMijna Hadders-Algra
May 10, 2020·Animals : an Open Access Journal From MDPI·Ximo Garcia-DominguezFrancisco Marco-Jiménez
Apr 11, 2018·Human Reproduction·Richard M Sharpe
Nov 20, 2020·International Journal of Molecular Sciences·Francisco Marco-JiménezJosé S Vicente
Apr 21, 2019·Fertility and Sterility·Jane HallidayRobert McLachlan
Oct 15, 2020·Cryobiology·Ximo Garcia-DominguezFrancisco Marco-Jiménez
Oct 14, 2021·Human Reproduction Update·Laura A WijsRoger J Hart

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