Developmental plasticity of NMDA receptor function in the retina and the influence of light

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Elke GuentherKonrad Kohler

Abstract

Despite the early expression of NMDA receptors (NMDARs) in the retina, not much is known about their regulation and involvement in plasticity processes during retinal development and synapse formation. Here we report that NMDAR function in the inner retina is developmentally regulated and controlled by ambient light condition. A prominent down-regulation after eye opening of NMDAR function was observed in rat retinal ganglion cells (RGCs), which was prevented by dark rearing the animals for 1 month but was again induced by subsequent light exposure. As shown by molecular analysis of single RGCs, alterations in the subunit composition of NMDAR did not account for the light-dependent regulation of NMDAR function. Immunocytochemistry showed no differences in the NMDAR protein expression pattern between normal and dark-reared animals. In conclusion, our data clearly demonstrate that NMDAR function is modulated during periods of retinal plasticity independent of structural alterations in its subunit composition and thus different from mechanisms observed in higher visual centers.

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Citations

Aug 3, 2013·Journal of Molecular Histology·Rai DilipMakoto Kaneda
Apr 19, 2011·Neurochemical Research·Georgia MantaAdamantia Mitsacos
Oct 13, 2009·Neuroscience Research·Makoto KanedaYukio Shimoda
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Mar 8, 2013·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Michael KalloniatisNiru Arunthavasothy
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Aug 30, 2018·Frontiers in Cellular Neuroscience·Eerik EliasNing Tian
Mar 6, 2012·Acta histochemica·Lily Alexandrova Vitanova

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