Developmental potential of somatic nuclei transplanted into meiotic oocytes of Rana pipiens

Science
N J Hoffner, M A DiBerardino

Abstract

Somatic nuclei, when transplanted into oocytes at the stage of first meiotic metaphase, were induced to undergo chromosome condensation and alignment on spindles. When the oocytes completed maturity in vitro and were activated, the somatic nuclei transformed into "fertilization" nuclei and promoted development through embryogenesis. Thus somatic nuclei can reversibly respond to cytoplasms directing either meiotic or mitotic events, and somatic nuclei from differentiated cells may be reversed by conditioning in oocytes.

References

Jan 1, 1979·International Review of Cytology·Y Masui, H J Clarke
Jan 1, 1980·Results and Problems in Cell Differentiation·M A DiBerardino, N J Hoffner
May 1, 1952·Proceedings of the National Academy of Sciences of the United States of America·R Briggs, T J King

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Citations

Nov 1, 1988·Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists·M A DiBerardino
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M A DiBerardinoR G McKinnell
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·N H OrrR G McKinnell
May 1, 1987·The Journal of Experimental Zoology·Y TsunodaT Sugie
Jan 1, 1983·Differentiation; Research in Biological Diversity·M A DiBerardinoD G Friesendorf
May 1, 1992·Differentiation; Research in Biological Diversity·M A Di Berardino, N H Orr
Jan 1, 1980·Differentiation; Research in Biological Diversity·M A DiBerardino
Jun 1, 1984·Science·M A DiBerardinoL D Etkin

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